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Zuberbühler, Klaus

Nom
Zuberbühler, Klaus
Affiliation principale
Fonction
Professeur ordinaire
Email
klaus.zuberbuehler@unine.ch
Identifiants
https://libra.unine.ch/handle/123456789/670
_
0000-0001-8378-088X

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  • Publication
    Métadonnées seulement
    Multiple Cross-Species Transmission Events of Human Adenoviruses (HAdV) during Hominine Evolution
    (2015)
    Hoppe, Eileen
    ;
    Pauly, Maude
    ;
    Gillespie, Thomas R.
    ;
    Akoua-Koffi, Chantal
    ;
    Hohmann, Gottfried
    ;
    Fruth, Barbara
    ;
    Karhemere, Stomy
    ;
    Madinda, Nadege F.
    ;
    Mugisha, Lawrence
    ;
    Muyembe, Jean-Jacques
    ;
    Todd, Angelique
    ;
    Petrzelkova, Klara J.
    ;
    Gray, Maryke
    ;
    Robbins, Martha
    ;
    Bergl, Richard A.
    ;
    Wittig, Roman M.
    ;
    Zuberbühler, Klaus 
    ;
    Boesch, Christophe
    ;
    Schubert, Grit
    ;
    Leendertz, Fabian H.
    ;
    Ehlers, Bernhard
    ;
    Calvignac-Spencer, Sebastien
    Human adenoviruses (HAdV; species HAdV-A to -G) are highly prevalent in the human population, and represent an important cause of morbidity and, to a lesser extent, mortality. Recent studies have identified close relatives of these viruses in African great apes, suggesting that some HAdV may be of zoonotic origin. We analyzed more than 800 fecal samples from wild African great apes and humans to further investigate the evolutionary history and zoonotic potential of hominine HAdV. HAdV-B and -E were frequently detected in wild gorillas (55%) and chimpanzees (25%), respectively. Bayesian ancestral host reconstruction under discrete diffusion models supported a gorilla and chimpanzee origin for these viral species. Host switches were relatively rare along HAdV evolution, with about ten events recorded in 4.5 My. Despite presumably rare direct contact between sympatric populations of the two species, transmission events from gorillas to chimpanzees were observed, suggesting that habitat and dietary overlap may lead to fecal-oral cross-hominine transmission of HAdV. Finally, we determined that two independent HAdV-B transmission events to humans occurred more than 100,000 years ago. We conclude that HAdV-B circulating in humans are of zoonotic origin and have probably affected global human health for most of our species lifetime.
  • Publication
    Métadonnées seulement
    Food sharing is linked to urinary oxytocin levels and bonding in related and unrelated wild chimpanzees
    (2014)
    Wittig, Roman M.
    ;
    Crockford, Catherine
    ;
    Deschner, Tobias
    ;
    Langergraber, Kevin E.
    ;
    Ziegler, Toni E.
    ;
    Zuberbühler, Klaus 
    Humans excel in cooperative exchanges between unrelated individuals. Although this trait is fundamental to the success of our species, its evolution and mechanisms are poorly understood. Other social mammals also build long-term cooperative relationships between non-kin, and recent evidence shows that oxytocin, a hormone involved in parent-offspring bonding, is likely to facilitate non-kin as well as kin bonds. In a population of wild chimpanzees, we measured urinary oxytocin levels following a rare cooperative event-food sharing. Subjects showed higher urinary oxytocin levels after single food-sharing events compared with other types of social feeding, irrespective of previous social bond levels. Also, urinary oxytocin levels following food sharing were higher than following grooming, another cooperative behaviour. Therefore, food sharing in chimpanzees may play a key role in social bonding under the influence of oxytocin. We propose that food-sharing events co-opt neurobiological mechanisms evolved to support mother-infant bonding during lactation bouts, and may act as facilitators of bonding and cooperation between unrelated individuals via the oxytocinergic system across social mammals.
  • Publication
    Métadonnées seulement
  • Publication
    Métadonnées seulement
    Wild Chimpanzees Inform Ignorant Group Members of Danger
    (2012)
    Crockford, Catherine
    ;
    Wittig, Roman M.
    ;
    Mundry, Roger
    ;
    Zuberbühler, Klaus 
    The ability to recognize other individuals' mental states their knowledge and beliefs, for example is a fundamental part of human cognition and may be unique to our species. Tests of a "theory of mind" in animals have yielded conflicting results [1-3]. Some nonhuman primates can read others' intentions and know what others see, but they may not understand that, in others, perception can lead to knowledge [1-3]. Using an alarm-call-based field experiment, we show that chimpanzees were more likely to alarm call in response to a snake in the presence of unaware group members than in the presence of aware group members, suggesting that they recognize knowledge and ignorance in others. We monitored the behavior of 33 individuals to a model viper placed on their projected travel path. Alarm calls were significantly more common if the caller was with group members who had either not seen the snake or had not been present when alarm calls were emitted. Other factors, such as own arousal, perceived risk, or risk to receivers, did not significantly explain the likelihood of calling, although they did affect the call rates. Our results suggest that chimpanzees monitor the information available to other chimpanzees and control vocal production to selectively inform them.
  • Publication
    Métadonnées seulement
    A Physiological Mechanism to Promote Social Bonding between Non-Kin: Evidence from Wild Chimpanzees
    (2011)
    Crockford, Catherine
    ;
    Wittig, Roman M.
    ;
    Ziegler, T.
    ;
    Deschner, Tobias
    ;
    Zuberbühler, Klaus