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The Prevalence and Incidence of Clinical and Asymptomatic Lyme Borreliosis in a Population at Risk
Auteur(s)
Fahrer, Heinz
van der Linden, Sjef M.
Sauvain, Marie-Josephe
Zhioua, Elyes
Date de parution
1991
In
Journal of Infectious Diseases (The), University of Chicago Press, 1991/163//305-310
Résumé
A past history of clinical Lyme borreliosis and the 6-month incidence of clinical and asymptomatic Lyme borreliosis was studied prospectively in a high-risk population. In the spring, blood samples were drawn from 950 Swiss orienteers, who also answered a questionnaire. IgG anti-<i>Borrelia burgdorferi</i> antibodies were detected by ELISA. Positive IgG antibodies were seen in 248 (26.1%), in contrast to 3.9%-6.0% in two groups of controls (n = 101). Of the orienteers, 1.9%-3.1% had a past history of definite or probable clinical Lyme borreliosis. Six months later a second blood sample was obtained from 755 participants, 558 (73.9%) of whom were seronegative initially; 45 (8.1%) had seroconverted from negative to positive. Only 1 (2.2%) developed clinical Lyme borreliosis. Among all participants, the 6-month incidence of clinical Lyme borreliosis was 0.8% (6/755) but was much higher (8.1%) for asymptomatic seroconversion (45/558). In conclusion, positive Lyme serology was common in Swiss orienteers, but clinical disease occurred infrequently.
Identifiants
Type de publication
journal article
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