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Characterization of a Novel Salivary Immunosuppressive Protein from <i>Ixodes ricinus</i> Ticks
Auteur(s)
Leboulle, Gérard
Crippa, Mara
Decrem, Yves
Mejri, Naceur
Bollen, Alex
Godfroid, Edmond
Date de parution
2002
In
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology (ASBMB), 2002/277/12/10083-10089
Résumé
In tick salivary glands, several genes are induced during the feeding process, leading to the expression of new proteins. These proteins are typically secreted in tick saliva and are potentially involved in the modulation of the host immune and hemostatic responses. In a previous study, the construction and the analysis of a subtractive library led to the identification of <i><u>I</u>xodes <u>r</u>icinus</i> <u>i</u>mmuno<u>s</u>uppressor (Iris), a novel protein, differentially expressed in <i>I. ricinus</i> salivary glands during the blood meal. In the present study, the data strongly suggest that this protein is secreted by tick salivary glands into the saliva. In addition, Iris is also found to modulate T lymphocyte and macrophage responsiveness by inducing a Th2 type response and by inhibiting the production of pro-inflammatory cytokines. In conclusion, these results suggest that Iris is an immunosuppressor, which might play an important role in the modulation of host immune response.
Identifiants
Type de publication
journal article
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