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Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages
Auteur(s)
Pitto-Barry, Anaïs
Zava, Olivier
Dyson, Paul J
In
Inorganic Chemistry, American Chemical Society, 2012/51/13/7119-7124
Résumé
Three generations of pyrenyl bis-MPA dendrimers with two different end-groups, acetonide (pyr<sub>Gn</sub>) or alcohol (pyr<sub>Gn-OH</sub>) (<i>n</i> = 1–3), were synthesized, and the pyrenyl group of the dendritic molecules was encapsulated in the arene ruthenium metallacages, [Ru<sub>6</sub>(<i>p</i>-cymene) <sub>6</sub> (OO∩OO)<sub>3</sub>(tpt)<sub>2</sub>]<sup>6+</sup> (OO∩OO = 5,8-dioxydo- 1,4-naphtaquinonato (donq) [1]<sup>6+</sup> and 6,11-dioxydo-5,12- naphtacenedionato (dotq) [2]<sup>6+</sup>; tpt =2,4,6-tri(pyridin-4-yl)-1,3,5-triazine). The host–guest properties of [guestC1]<sup>6+</sup> and [guestC2]<sup>6+</sup> were studied in solution by NMR and UV–vis spectroscopic methods, thus allowing the determination of the affinity constants. Moreover, the cytotoxicity of these water- soluble host–guest systems and the pyrenyl-dendrimers was evaluated on human ovarian cancer cells.
Identifiants
Type de publication
journal article
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