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Excellent Correlation between Drug Release and Portal Size in Metalla-Cage Drug-Delivery Systems
Auteur(s)
Date de parution
2011
In
Chemistry - A European Journal, Wiley, 2011/17/35/9669-9677
Résumé
A series of large cationic hexanuclear metalla-prisms, [Ru<sub>6</sub>(<i>p-i</i>PrC<sub>6</sub>H<sub>4</sub>Me)<sub>6</sub>(tpt)<sub>2</sub>(donq)<sub>3</sub>]<sup>6+</sup>, [Ru<sub>6</sub>(<i>p-i</i>PrC<sub>6</sub>H<sub>4</sub>Me)<sub>6</sub>(tpt)<sub>2</sub>(doaq)<sub>3</sub>]<sup>6+</sup> and [Ru<sub>6</sub>(<i>p-i</i>PrC<sub>6</sub>H<sub>4</sub>Me)<sub>6</sub>(tpt)<sub>2</sub>(dotq)<sub>3</sub>]<sup>6+</sup>, composed of <i>p</i>-cymene–ruthenium building blocks bridged by OO∩OO ligands (donq=5,8-dioxido-1,4-naphthoquinonato; doaq=5,8-dioxido-1,4-anthraquinonato, dotq=6,11-dioxido-5,12-naphthacenedionato) and connected by two 2,4,6-tripyridin-4-yl-1,3,5-triazine (tpt) panels, which encapsulate the guest molecules 1-(4,6-dichloro-1,3,5-triazin-2-yl)pyrene and Pd(acac)<sub>2</sub>, have been prepared. The host–guest properties of these water-soluble delivery systems were studied in solution by NMR and fluorescence spectroscopy, providing the stability constants (<i>K</i>) for these host–guest systems. Moreover, the ability of the hosts to deliver the guests into cancer cells was evaluated and the uptake mechanism studied; the rate of release of the guest molecule was found to depend on the portal size of the host.
Identifiants
Type de publication
journal article
