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Thiolato-Bridged Arene–Ruthenium Complexes: Synthesis, Molecular Structure, Reactivity, and Anticancer Activity of the Dinuclear Complexes [(arene)<sub>2</sub>Ru<sub>2</sub> (SR)<sub>2</sub>Cl<sub>2</sub>]
Auteur(s)
Ibao, Anne-Flore
Gras, Michaël
Zava, Olivier
Dyson, Paul J.
Date de parution
2012
In
European Journal of Inorganic Chemistry, Wiley, 2012/2012/9/1531-1535
Résumé
Treatment of an arene–ruthenium dichloride dimer with thiols RSH to lead to cationic trithiolato complexes of the type [(arene) <sub>2</sub>Ru<sub>2</sub>(SR)<sub>3</sub>]<sup>+</sup> was shown to proceed through the neutral thiolato complexes [(arene)<sub>2</sub>Ru<sub>2</sub>(SR)<sub>2</sub>Cl<sub>2</sub>], which have been isolated and characterized for arene = <i>p</i>-MeC<sub>6</sub>H<sub>4</sub><i>i</i>Pr and R = CH<sub>2</sub>Ph (<b>1</b>), CH<sub>2</sub>CH<sub>2</sub>Ph (<b>2</b>), CH<sub>2</sub>C<sub>6</sub>H<sub>4</sub>-<i>p-t</i>Bu (<b>3</b>), and C<sub>6</sub>H<sub>11</sub> (<b>4</b>). The single-crystal X-ray structure analysis of the <i>p-tert</i>-butylbenzyl derivative <b>3</b> reveals that the two ruthenium atoms are bridged by the two thiolato ligands without a metal–metal bond. The neutral dithiolato complexes[(arene)<sub>2</sub>Ru<sub>2</sub>(SR)<sub>2</sub>Cl<sub>2</sub>] (<b>1–3</b>) are intermediates in the formation of the cationic trithiolato complexes [(arene)<sub>2</sub>Ru<sub>2</sub>(SR)<sub>3</sub>]<sup>+</sup> (<b>5–7</b>). Of the new [(arene)<sub>2</sub>Ru<sub>2</sub>(SR)<sub>2</sub>Cl<sub>2</sub>] complexes, derivative 2 is highly cytotoxic against human ovarian cancer cells, with IC<sub>50</sub> values of 0.20 μM for the A2780 cell line and 0.31 for the cisplatin-resistant cell line A2780cisR.
Identifiants
Type de publication
journal article
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