Options
Synthesis of novel and stable 5-aminolevulinic acid derivatives for the efficient synthesis of 5-aminolevulinic acid based prodrugs
Auteur(s)
Vallinayagam, Ramakrishnan
Bertschy, Hugo
Berger, Yann
Wenger, Virginie
Date de parution
2007
In
Synthesis
Vol.
23
De la page
3731
A la page
3735
Mots-clés
- Esters Role: SPN (Synthetic preparation)
- PREP (Preparation) (aliphatic
- prepn. of aminolevulinic acid derivs. via bromination/methylation of oxopentanoic acid followed by azidation
- hydrogenation
- Boc-protection
- demethylation and esterification with pentafluorophenol
- trichloroethanol or acetone oxime)
- Esterification (prepn. of aminolevulinic acid derivs. via bromination/methylation of oxopentanoic acid followed by azidation
- hydrogenation
- Boc-protection
- demethylation and esterification with pentafluorophenol
- trichloroethanol or acetone oxime)
- aminolevulinic acid deriv prepn
Résumé
The efficient synthesis of two stable, easily handled precursors of 5-aminolevulinate is reported. These precursors are stable to the chem. transformation needed for the synthesis of bioconjugates and can be readily deprotected in good yields. [on SciFinder(R)]
Identifiants
Type de publication
journal article
