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High-density electrode array for imaging in vitro electrophysiological activity
Auteur(s)
Berdondini, Luca
van der Wal, P.D.
Guenat, Olivier
de Rooij, Nicolaas F.
Koudelka-Hep, Milena
Seitz, P.
Kaufmann, R.
Metzler, P.
Blanc, N.
Rohr, S.
Date de parution
2005
In
Biosensors and Bioelectronics, Elsevier, 2005/21/1/167
Résumé
The development of a high-density active microelectrode array for in vitro electrophysiology is reported. Based on the Active Pixel Sensor (APS) concept, the array integrates 4096 gold microelectrodes (electrode separation 20 μm) on a surface of 2.5 mm × 2.5 mm as well as a high-speed random addressing logic allowing the sequential selection of the measuring pixels. Following the electrical characterization in a phosphate solution, the functional evaluation has been carried out by recording the spontaneous electrical activity of neonatal rat cardiomyocytes. Signals with amplitudes from 130 μV<sub>p-p</sub> to 300 μV<sub>p-p</sub> could be recorded from different pixels. The results demonstrate the suitability of the APS concept for developing a new generation of high-resolution extracellular recording devices for in vitro electrophysiology.
Identifiants
Type de publication
journal article
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