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Organometallic Cages as Vehicles for Intracellular Release of Photosensitizers
Auteur(s)
Schmitt, Frédéric
Barry, Nicolas P.E.
Juillerat-Jeanneret, Lucienne
Date de parution
2012
In
Journal of the American Chemical Society (JACS), American Chemical Society (ACS), 2012/134/2/754-757
Résumé
Water-soluble metalla-cages were used to deliver hydrophobic porphin molecules to cancer cells. After internalization, the photosensitizer was photoactivated, significantly increasing the cytotoxicity in cells. During the transport, the photosensitizer remains nonreactive to light, offering a new strategy to tackle overall photosensitization, a limitation often encountered in photodynamic therapy.
Identifiants
Type de publication
journal article
