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Neutral and cationic osmium(II)-arene metallodendrimers: Synthesis, characterisation and anticancer activity

Auteur(s)
Govender, Preshendren
Edafe, Fabio
Makhubela, Banothile C. E.
Dyson, Paul J.
Smith, Gregory S.
Date de parution
2014
In
Inorg. Chim. Acta
Vol.
PB
No
409
De la page
112
A la page
120
Mots-clés
Résumé
Two neutral and two cationic half-sandwich Os(II)-arene metallodendrimers, [DAB-PPI-{(?6-p-cym)Os((C7H5NO)-?2-N,O)Cl}n] and [DAB-PPI-{(?6-p-cym)Os((C6H5N2)-?2-N,N)Cl}n][PF6]n (n = 4 (G1) or 8 (G2)) were synthesized. Two cationic half-sandwich Os(II)-arene metallodendrimers, contg. PTA (1,3,5-triaza-7-phosphatricyclo[3.3.1.1.] decane), [DAB-PPI-{(?6-p-cym)Os((C7H5NO)-?2-N,O)PTA}n][PF6]n are also reported. All complexes were characterized using anal. (i.e. HR-ESI or EI mass spectrometry and elemental anal.) and spectroscopic (i.e.1H, 13C{1H} NMR and IR) methods. Model mononuclear analogs were prepd. and their mol. structures detd. by single-crystal x-ray crystallog. The cytotoxicity of the complexes were evaluated against the A2780 and A2780cisR human ovarian carcinoma cell lines and some display moderate activity. [on SciFinder(R)]
Identifiants
https://libra.unine.ch/handle/123456789/11679
Type de publication
journal article