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Catalytic and anticancer activities of sawhorse-type diruthenium tetracarbonyl complexes derived from fluorinated fatty acids
Auteur(s)
Johnpeter, Justin P.
Plasseraud, Laurent
Schmitt, Frederic
Juillerat-Jeanneret, Lucienne
Date de parution
2013
In
J. Coord. Chem.
Vol.
10
No
66
De la page
1753
A la page
1762
Résumé
The reaction of fluorinated fatty acids, perfluorobutyric acid (C3F7CO2H), and perfluorododecanoic acid (C11F23CO2H), with dodecacarbonyltriruthenium (Ru3(CO)12) under reflux in THF, followed by addn. of two-electron donors (L) such as pyridine, 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane, or triphenylphosphine, gives stable diruthenium complexes Ru2(CO)4(?2-?2-O2CC3F7)2(L)2 (1a, L = C5H5N; 1b, L = PTA; 1c, L = PPh3) and Ru2(CO)4(?2-?2-O2CC11F23)2(L)2 (2a, L = C5H5N; 2b, L = PTA; 2c, L = PPh3). The catalytic activity of the complexes for hydrogenation of styrene under supercrit. carbon dioxide was assessed and compared to the analogous triphenylphosphine complexes with nonfluorinated carboxylato groups Ru2(CO)4(?2-?2-O2CC3H7)2(PPh3)2 (3) and Ru2(CO)4(?2-?2-O2CC11H23)2(PPh3)2 (4). The cytotoxicities of the fluorinated complexes were also evaluated on several human cancer cell lines (A2780, A549, Me300, HeLa). The complexes appear to be moderately cytotoxic, showing greater activity on the Me300 melanoma cells. Single-crystal x-ray structure analyses of 1a and 3 show the typical sawhorse-type arrangement of the diruthenium tetracarbonyl backbone with two bridging carboxylates and two terminal ligands occupying the axial positions. [on SciFinder(R)]
Identifiants
Type de publication
journal article
