Options
Synthesis and Anticancer Activity of Long-Chain Isonicotinic Ester Ligand-Containing Arene Ruthenium Complexes and Nanoparticles
Auteur(s)
Khan, Farooq-Ahmad
Juillerat-Jeanneret, Lucienne
Dyson, Paul J.
Renfrew, Anna K.
Date de parution
2010
In
Journal of Cluster Science, Springer, 2010/21/3/313-324
Résumé
Arene ruthenium complexes containing long-chain <i>N</i>-ligands L<sup>1</sup> = NC<sup>5</sup>H<sup>4</sup>–4-COO–C<sup>6</sup>H<sup>4</sup>–4-O–(CH<sup>2</sup>)<sup>9</sup>–CH<sup>3</sup> or L<sup>2</sup> = NC<sup>5</sup>H<sup>4</sup>–4-COO–(CH<sup>2</sup>)<sup>10</sup>–O–C<sup>6</sup>H<sup>4</sup>–4-COO–C<sup>6</sup>H<sup>4</sup>–4-C<sup>6</sup>H<sup>4</sup>–4-CN derived from isonicotinic acid, of the type [(arene)Ru(L)Cl<sup>2</sup>] (arene = C<sup>6</sup>H<sup>6</sup>, L = L<sup>1</sup>: <b>1</b>; arene = <i>p</i>-MeC<sup>6</sup>H<sup>4</sup>Pr <sup><i>i</i></sup> , L = L<sup>1</sup>: <b>2</b>; arene = C<sup>6</sup>Me<sup>6</sup>, L = L<sup>1</sup>: <b>3</b>; arene = C<sup>6</sup>H<sup>6</sup>, L = L<sup>2</sup>: <b>4</b>; arene = <i>p</i>-MeC<sup>6</sup>H<sup>4</sup>Pr <sup><i>i</i></sup> , L = L<sup>2</sup>: <b>5</b>; arene = C<sup>6</sup>Me<sup>6</sup>, L = L<sup>2</sup>: <b>6</b>) have been synthesized from the corresponding [(arene)RuCl<sup>2</sup>]<sup>2</sup> precursor with the long-chain <i>N</i>-ligand L in dichloromethane. Ruthenium nanoparticles stabilized by L<sup>1</sup> have been prepared by the solvent-free reduction of <b>1</b> with hydrogen or by reducing [(arene)Ru(H<sup>2</sup>O)<sup>3</sup>]SO<sup>4</sup> in ethanol in the presence of L<sup>1</sup> with hydrogen. These complexes and nanoparticles show a high anticancer activity towards human ovarian cell lines, the highest cytotoxicity being obtained for complex <b>2</b> (IC<sup>50</sup> = 2 μM for A2780 and 7 μM for A2780cisR).
Identifiants
Type de publication
journal article
