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Efficient Oxidation of Cysteine and Glutathione Catalyzed by a Dinuclear Areneruthenium Trithiolato Anticancer Complex
Auteur(s)
Date de parution
2011
In
Inorganic Chemistry, American Chemical Society (ACS), 2011/50/21/10552–10554
Résumé
The highly cytotoxic diruthenium complex [(<i>p</i>-MeC<sub>6</sub>H<sub>4</sub>Pr<sup>i</sup>)<sub>2</sub>Ru<sub>2</sub>(SC<sub>6</sub>H<sub>4</sub>-<i>p</i>-Me)<sub>3</sub>]<sup>+</sup> (<b>1</b>), water-soluble as the chloride salt, is shown to efficiently catalyze oxidation of the thiols cysteine and glutathione to give the corresponding disulfides, which may explain its high in vitro anticancer activity.
Identifiants
Type de publication
journal article
