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Synthesis, characterisation and in vitro anticancer activity of hexanuclear thiolato-bridged arene ruthenium metalla-prisms
Auteur(s)
Furrer, Mona A.
Denoyelle-Di-Muro, Emmanuel
Trouillas, Patrick
Giannini, Federico
Furrer, Julien
Clavel, Catherine M.
Dyson, Paul J.
Date de parution
2013
In
Chem. - Eur. J.
Vol.
9
No
19
De la page
3198
A la page
3203
Résumé
Hexanuclear hexacationic thiolato-bridged arene ruthenium metalla-prisms of the general formula [[(?6-p-cymene)Ru]6(?-SR)6(?3-tpt)2][OTf]6 (R = CH2Ph, CH2C6H4-p-tBu, CH2CH2Ph; tpt = 2,4,6-tri-4-pyridyl-1,3,5-triazine), obtained from the self-assembly of dinuclear precursors [(p-cymene)2Ru2(?-SR)2Cl2] with tpt and AgCF3SO3, have been isolated and fully characterized as triflate salts. The metalla-prisms are highly cytotoxic against human ovarian cancer cells, esp. towards the cisplatin-resistant cell line A2780cisR (IC50
Identifiants
Type de publication
journal article
