Options
Prophylaxis failure due to probable mefloquine resistant P-falciparum from Tanzania
Auteur(s)
Date de parution
2003
In
Acta Tropica
Vol.
1
No
86
De la page
63
A la page
65
Résumé
Failures of mefloquine prophylaxis in travellers returning from Africa have been reported repeatedly. Noncompliance to chemoprophylaxis is considered to be a major factor for failure. Only few reports on mefloquine prophylaxis failure in sub-Saharan Africa were able to report blood levels of the drug that were sufficient for prophylactic effectiveness. We report the case of a 44-year-old German female who travelled to Tanzania for 3 weeks. The patient reported that she never missed a dose of mefloquine during her weekly prophylaxis schedule. Four weeks after returning from Tanzania, the patient presented with fever, headache and myalgia. Only a few trophozoites of Plasmodium falciparum were found in a thick film. Blood levels of mefloquine at that stage were at 1400 ng/ml, thus largely excluding non-compliance and malabsorption. To our knowledge, this is the first case of confirmed prophylaxis failure due to mefloquine resistance in East Africa. (C) 2003 Elsevier Science B.V. All rights reserved.
Identifiants
Type de publication
journal article
