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Anticancer activity of tetracationic arene ruthenium metalla-cycles
Auteur(s)
Date de parution
2011
In
Dalton Transactions, Royal Society of Chemistry (RSC)
Vol.
140
No
27
De la page
7172
A la page
7180
Résumé
A series of cationic metalla-cycles of the general formulae [(η<sup>6</sup>-<i>p</i>-cym)<sub>4</sub>Ru<sub>4</sub>(<i>OO</i>∩<i>OO</i>)<sub>2</sub>(<i>N</i>∩<i>N</i>)<sub>2</sub>]<sup>4+</sup> and [(η<sup>6</sup>-<i>p</i>-cym)<sub>4</sub>Ru<sub>4</sub>(<i>NO</i>∩<i>NO</i>)<sub>2</sub>(<i>N</i>∩<i>N</i>)<sub>2</sub>]<sup>4+</sup> has been prepared from the dinuclear arene ruthenium precursors [(η<sup>6</sup>-<i>p</i>-cym)<sub>2</sub>Ru<sub>2</sub>(<i>OO</i>∩<i>OO</i>)<sub>2</sub>Cl<sub>2</sub>] (<i>OO</i>∩<i>OO</i> = oxalato, 1,4-benzoquinonato-2,5-diolato, 1,4-naphtoquinonato-5,8-diolato, 9,10-anthraquinonato-1,4-diolato, 5,12-tetraquinonato-6,11-diolato) and [(η<sup>6</sup>-<i>p</i>-cym)<sub>2</sub>Ru<sub>2</sub>(<i>NO</i>∩<i>NO</i>)<sub>2</sub>Cl<sub>2</sub>] (<i>NO</i>∩<i>NO</i> = oxamido, oxonico) by reaction with two different bidentate linkers (<i>N</i>∩<i>N</i> = 1,2-bis(4-pyridyl)ethylene, 1,2-bis(4-pyridyl)ethane) in the presence of silver triflate. All complexes were isolated as triflate salts and characterised by NMR, infrared, UV-visible, mass spectrometry and by elemental analysis. The cytotoxicities of the tetranuclear ruthenium complexes have been established using ovarian A2780 and A2780cisR cancer cell lines. All complexes exhibit moderate to excellent activity on both the cisplatin resistant and cisplatin sensitive cells, thus suggesting a mode of action different from cisplatin.
Identifiants
Type de publication
journal article
