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Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole <i>N</i>,<i>N</i>-chelating ligand
Auteur(s)
Gras, Michaël
Angela Casini
Edafe, Fabio
Paul Dyson
Maison d'édition
Elsevier
Date de parution
2010
In
Journal of Organometallic Chemistry
Vol.
695
De la page
1119
A la page
1125
Résumé
The dinuclear dichloro complexes [(η<sup>6</sup>-arene)<sub>2</sub>Ru<sub>2</sub>(μ-Cl)<sub>2</sub>Cl<sub>2</sub>] and [(η<sup>5</sup>-C<sub>5</sub>Me<sub>5</sub>)<sub>2</sub>M<sub>2</sub> (μ-Cl)<sub>2</sub>Cl<sub>2</sub>] react with 2-(pyridine-2-yl)thiazole (pyTz) to afford the cationic complexes [(η<sup>6</sup>-arene)Ru(pyTz)Cl]<sup>+</sup> (arene = C<sub>6</sub>H<sub>6</sub><b>1</b>, <i>p-<sup>i</sup></i>PrC<sub>6</sub>H<sub>4</sub>Me <b>2</b> or C<sub>6</sub>Me<sub>6</sub><b>3</b>) and [(η<sup>5</sup>-C<sub>5</sub>Me<sub>5</sub>)M(pyTz)Cl]<sup>+</sup> (M = Rh <b>4</b> or Ir <b>5</b>), isolated as the chloride salts. The reaction of <b>2</b> and <b>3</b> with SnCl<sub>2</sub> leads to the dinuclear heterometallic trichlorostannyl derivatives [(η<sup>6</sup>-<i>p-<sup>i</sup></i>PrC<sub>6</sub>H<sub>4</sub>Me)Ru(pyTz)(SnCl<sub>3</sub>)]<sup>+ </sup> (<b>6</b>) and [(η<sup>6</sup>-C<sub>6</sub>Me<sub>6</sub>)Ru(pyTz)(SnCl<sub>3</sub>)]<sup>+</sup> (<b>7</b>), respectively, also isolated as the chloride salts. The molecular structures of <b>4</b>, <b>5</b> and <b>7</b> have been established by single-crystal X-ray structure analyses of the corresponding hexafluorophosphate salts. The <i>in vitro</i> anticancer activities of the metal complexes on human ovarian cancer cell lines A2780 and A2780cisR (cisplatin-resistant), as well as their interactions with plasmid DNA and the model protein ubiquitin, have been investigated.
Identifiants
Type de publication
journal article
