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Synthesis, Molecular Structure, and Anticancer Activity of Cationic Arene Ruthenium Metallarectangles
Auteur(s)
Mattsson, Johan
Govindaswamy, Padavattan
Renfrew, Anna K.
Dyson, Paul J.
Štěpnička, Petr
Date de parution
2009
In
Organometallics, American Chemical Society (ACS), 2009/28/15/4350–4357
Résumé
The cytotoxicities of a new series of cationic metallarectangles have been established in the A2780 ovarian cancer cell line. Interestingly, the large rectangles incorporating 1,2-bis(4-pyridyl)ethylene linkers are ca. 5 times more cytotoxic (IC<sub>50</sub> ≤ 6 μM) than the 4,4-bipyridine analogues (IC<sub>50</sub> ≥ 30 μM), thus suggesting a correlation between cytotoxicity and the size of the rectangle.
Identifiants
Type de publication
journal article
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