Options
Anticancer activity of osmium metalla-rectangles
Auteur(s)
Date de parution
2010
In
Dalton Transactions, Royal Society of Chemistry (RSC)
Vol.
39
No
11
De la page
2816
A la page
2820
Résumé
A series of cationic metalla-rectangles of the general formula [(<i>p</i>-cymene)<sub>4</sub>Os<sub>4</sub>(<i>O</i>O∩O<i>O</i>)<sub>2</sub>(<i>N</i>∩<i>N</i>)<sub>2</sub>]<sup>4+</sup> have been obtained in methanol from the dinuclear arene osmium precursors [(<i>p</i>-cymene)<sub>2</sub>Os<sub>2</sub> (<i>O</i>O∩O<i>O</i>)<sub>2</sub>Cl<sub>2</sub>] (<i>O</i>O∩O<i>O</i> = 2,5-dioxydo-1,4-benzoquinonato (dhbq), 2,5-dichloro-1,4-benzoquinonato (dcbq)) by reaction with bipyridine linkers (<i>N</i>∩<i>N</i> = 4,4′-bipyridine, 1,2-bis(4-pyridyl)ethylene) in the presence of AgCF<sub>3</sub>SO<sub>3</sub>. All complexes were isolated as triflate salts and characterised by NMR, IR and UV-visible spectroscopy. The cytotoxicities of the dinuclear and tetranuclear osmium complexes were established using ovarian A2780 cancer cell lines. The most active metalla-rectangle, [(<i>p</i>-cymene)<sub>4</sub>Os<sub>4</sub>(dhbq)<sub>2</sub>(4,4′-bipyridine)<sub>2</sub>]<sup>4+</sup>, shows an IC<sub>50</sub> value of 5.7 μM (comparable to cisplatin) against A2780 cancer cells and 7.5 μM against the cisplatin resistant A2780cisR cells.
Identifiants
Type de publication
journal article
