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Mono- and dinuclear (η<sup>6</sup>-arene) ruthenium(II) benzaldehyde thiosemicarbazone complexes: Synthesis, characterization and cytotoxicity
Auteur(s)
Stringer, Tameryn
Hendricks, Denver T.
Guzgay, Hajira
Smith, Gregory S.
Stringer, Tameryn
Hendricks, Denver T.
Guzgay, Hajira
Smith, Gregory S.
Date de parution
2011
In
Inorganic Chemistry Communications, Elsevier, 2011/14/6/956–960
Résumé
A series of mono- and dinuclear (η<sup>6</sup>-arene) ruthenium(II) complexes were prepared by reaction of thiosemicarbazone ligands derived from benzaldehyde and ruthenium(II) precursors of the general formula [Ru(η<sup>6</sup>-arene)(μ-Cl)Cl]<sup>2</sup>, where arene = <i>p-<sup>i</sup></i>PrC<sup>6</sup>H<sup>4</sup>Me or C<sup>6</sup>H<sup>5</sup>C<sup>3</sup>H<sup>6</sup>COOH. These complexes were characterized by NMR and IR spectroscopy, ESI-mass spectrometry and elemental analysis. The molecular structure of the mononuclear <i>p</i>-cymene complex was determined by X-ray diffraction analysis, revealing a pseudo-tetrahedral piano stool conformation and a bidentate <i>N,S</i> coordination mode of the thiosemicarbazone ligand. The complexes and ligands were evaluated for their <i>in vitro</i> cytotoxicity against the WHCO1 oesophageal cancer cell line.
Identifiants
Type de publication
journal article
