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Encapsulation of Pyrene-Functionalized Poly(benzyl ether) Dendrons into a Water-Soluble Organometallic Cage
Auteur(s)
Pitto-Barry, Anaïs
Barry, Nicolas P. E.
Zava, Olivier
Date de parution
2011
In
Chemistry – An Asian Journal, Wiley, 2011/6/6/1595-1603
Résumé
Two generations of lipophilic pyrenyl functionalized poly(benzyl ether) dendrimers (P<sub>1</sub> and P<sub>2</sub>) have been synthesized. The thermal properties of the two functionalized dendrimers have been investigated, and the pyrenyl group of the dendritic molecules encapsulated in the arene–ruthenium metalla-cage, [Ru<sub>6</sub>(<i>p</i>-cymene)<sub>6</sub>(tpt)<sub>2</sub>(donq)<sub>3</sub>]<sup>6+</sup> ([<b>1</b>]<sup>6+</sup>) (tpt=2,4,6-tri(pyridin-4-yl)-1,3,5-triazine; donq=5,8-dioxydo-1,4-naphthoquinonato). The host–guest properties of [P1⊂<b>1</b>]<sup>6+</sup> and [P2⊂<b>1</b>]<sup>6+</sup> were studied in solution by NMR and UV/Vis spectroscopic methods, thus allowing the determination of the affinity constants. Moreover, the cytotoxicity of these water-soluble host–guest systems was evaluated on human ovarian cancer cells.
Identifiants
Type de publication
journal article
