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(Strept)avidin as Host for Biotinylated Coordination Complexes: Stability, Chiral Discrimination, and Cooperativity
Auteur(s)
Loosli, Andreas
Rusbandi, Untung Edy
Gradinaru, Julieta
Bernauer, Klaus
Schlaepfer, Carl Wilhelm
Meyer, Michel
Mazurek, Sylwester
Novic, Marjana
Ward, Thomas R.
Date de parution
2006
In
Inorganic Chemistry, American Chemical Society (ACS), 2006/45/2/660-668
Résumé
To determine the stepwise association constants, to assess cooperativity and chiral discrimination properties of (strept)avidin toward biotinylated coordination complexes, diastereopure [Ru(bpy)<sub>2</sub>(Biot-bpy)]<sup>2+</sup> (<b>1</b>) complexes were synthesized. Analysis of the CD titration data suggests a strong cooperativity between the first and the second binding events in tetrameric (strept)avidin and a pronounced difference in affinity between avidin and streptavidin for the dicationic guest <b>1</b> as well as modest enantiodiscrimination properties with avidin as host.
Identifiants
Type de publication
journal article
