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  4. Artificial Metalloenzymes for Enantioselective Catalysis Based on the Noncovalent Incorporation of Organometallic Moieties in a Host Protein
 
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Artificial Metalloenzymes for Enantioselective Catalysis Based on the Noncovalent Incorporation of Organometallic Moieties in a Host Protein

Auteur(s)
Ward, Thomas R.
Date de parution
2005-03-10
In
Chemistry - A European Journal, 2005/11/3798-3803
Mots-clés
  • artificial metalloenz...

  • asymmetric catalysis

  • biotin-avidin technol...

  • chemogenetic optimiza...

  • hydrogenation

Résumé
Enzymatic and homogeneous catalysis offer complementary means to produce enantiopure products. Incorporation of achiral, biotinylated aminodiphosphine-rhodium complexes in (strept)avidin affords enantioselective hydrogenation catalysts. A combined chemogenetic procedure allows the optimization of the activity and the selectivity of such artificial metalloenzymes: the reduction of acetamidoacrylate proceeds to produce N-acetamidoalanine in either 96 % ee (<sup>R</sup>) or 80 % ee (<sup>S</sup>). In addition to providing a chiral second coordination sphere and, thus, selectivity to the catalyst, the phenomenon of protein-accelerated catalysis (e.g., increased activity) was unraveled. Such artificial metalloenzymes based on the biotin-avidin technology display features that are reminiscent of both homogeneous and of enzymatic catalysis.
URI
https://libra.unine.ch/handle/123456789/18903
DOI
10.1002/chem.200401232
Autre version
http://dx.doi.org/10.1002/chem.200401232
Type de publication
Resource Types::text::journal::journal article
Dossier(s) à télécharger
 main article: 1_Ward_Thomas_R._-_Artificial_Metalloenzymes_for_Enantioselective_Catalysis_20060331.pdf (803.28 KB)
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