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  4. Synthesis of novel and stable 5-aminolevulinic acid derivatives for the efficient synthesis of 5-aminolevulinic acid based prodrugs
 
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Synthesis of novel and stable 5-aminolevulinic acid derivatives for the efficient synthesis of 5-aminolevulinic acid based prodrugs

Auteur(s)
Vallinayagam, Ramakrishnan
Bertschy, Hugo
Berger, Yann
Wenger, Virginie
Neier, Reinhard 
Institut de chimie 
Date de parution
2007
In
Synthesis
Vol.
23
De la page
3731
A la page
3735
Mots-clés
  • Esters Role: SPN (Synthetic preparation)
  • PREP (Preparation) (aliphatic
  • prepn. of aminolevulinic acid derivs. via bromination/methylation of oxopentanoic acid followed by azidation
  • hydrogenation
  • Boc-protection
  • demethylation and esterification with pentafluorophenol
  • trichloroethanol or acetone oxime)
  • Esterification (prepn. of aminolevulinic acid derivs. via bromination/methylation of oxopentanoic acid followed by azidation
  • hydrogenation
  • Boc-protection
  • demethylation and esterification with pentafluorophenol
  • trichloroethanol or acetone oxime)
  • aminolevulinic acid deriv prepn
  • Esters Role: SPN (Syn...

  • PREP (Preparation) (a...

  • prepn. of aminolevuli...

  • hydrogenation

  • Boc-protection

  • demethylation and est...

  • trichloroethanol or a...

  • Esterification (prepn...

  • hydrogenation

  • Boc-protection

  • demethylation and est...

  • trichloroethanol or a...

  • aminolevulinic acid d...

Résumé
The efficient synthesis of two stable, easily handled precursors of 5-aminolevulinate is reported. These precursors are stable to the chem. transformation needed for the synthesis of bioconjugates and can be readily deprotected in good yields. [on SciFinder(R)]
Identifiants
https://libra.unine.ch/handle/123456789/21490
Type de publication
journal article
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