Therrien, Bruno

2010, Gras, Michaël, Süss-Fink, Georg, Therrien, Bruno, Angela Casini, Edafe, Fabio, Paul Dyson

The dinuclear dichloro complexes [(η⁶-arene)₂Ru₂(μ-Cl)₂Cl₂] and [(η⁵-C₅Me₅)₂M₂ (μ-Cl)₂Cl₂] react with 2-(pyridine-2-yl)thiazole (pyTz) to afford the cationic complexes [(η⁶-arene)Ru(pyTz)Cl]⁺ (arene = C₆H₆1, p-ⁱPrC₆H₄Me 2 or C₆Me₆3) and [(η⁵-C₅Me₅)M(pyTz)Cl]⁺ (M = Rh 4 or Ir 5), isolated as the chloride salts. The reaction of 2 and 3 with SnCl₂ leads to the dinuclear heterometallic trichlorostannyl derivatives [(η⁶-p-ⁱPrC₆H₄Me)Ru(pyTz)(SnCl₃)]⁺ (6) and [(η⁶-C₆Me₆)Ru(pyTz)(SnCl₃)]⁺ (7), respectively, also isolated as the chloride salts. The molecular structures of 4, 5 and 7 have been established by single-crystal X-ray structure analyses of the corresponding hexafluorophosphate salts. The in vitro anticancer activities of the metal complexes on human ovarian cancer cell lines A2780 and A2780cisR (cisplatin-resistant), as well as their interactions with plasmid DNA and the model protein ubiquitin, have been investigated.

2009, Thai, Trieu-Tien, Therrien, Bruno, Süss-Fink, Georg

The neutral chloro complexes [(η⁵-C₅Me₅)M(η²-NC₉H₆O)Cl] as well as the cationic aqua complexes [(η⁵-C₅Me₅)M(η²-NC₉H₆O)(H₂O)]⁺ (M = Rh, Ir) have been synthesized from the reaction of the dinuclear precursors [(η⁵-C₅Me₅)MCl₂]₂ and 8-hydroxyquinoline. The single crystal X-ray structure analysis of [(η⁵-C₅Me₅)Ir(η²-NC₉H₆O)Cl] reveals for these complexes a piano-stool arrangement with the aromatic ligand, the chelating oxinato ligand and the terminal chloro or aqua ligand surrounding the metal center in a pseudo-tetrahedral fashion.

2007, Govindaswamy, Padavattan, Therrien, Bruno, Süss-Fink, Georg, Štěpnička, Petr, Ludvík, Jiří

The mononuclear complexes [(η⁵-C₅Me₅)IrCl(L¹)] (1), [(η⁵-C₅Me₅)RhCl(L¹)] (2), [(η⁶-p-PriC₆H₄Me)RuCl(L¹)] (3) and [(η⁶-C₆Me₆)RuCl(L¹)] (4) have been synthesised from pyrazine-2-carboxylic acid (HL¹) and the corresponding complexes [{(η⁵-C₅Me₅)IrCl₂}₂], [{(η⁵-C₅Me₅)RhCl₂}₂], [{(η⁶-p-PrⁱC₆H₄Me)RuCl₂}₂], and [{(η⁶-C₆Me₆)RuCl₂}₂], respectively. The related dinuclear complexes [{(η⁵-C₅Me₅)IrCl}₂ (μ-L²)] (5), [{(η⁵-C₅Me₅)RhCl}₂ (μ-L²)] (6), [{(η⁶-p-PrⁱC₆H₄Me)RuCl}₂ (μ-L²)] (7) and [{(η⁶-C₆Me₆)RuCl}₂ (μ-L²)] (8) have been obtained in a similar manner from pyrazine-2,5-dicarboxylic acid (H₂L₂). Compounds isomeric to the latter series, [{(η⁵-C₅Me₅)IrCl}₂ (μ-L³)] (9), [{(η⁵-C₅Me₅)RhCl}₂ (μ-L³)] (10), [{(p-PrⁱC₆H₄Me)RuCl}₂ (μ-L³)] (11) and [{(η⁶-C₆Me₆)RuCl}₂ (μ-L³)] (12), have been prepared by using pyrazine-2,3-dicarboxylic acid (H₂L₃) instead of H₂L₂. The molecular structures of 2 and 3, determined by X-ray diffraction analysis, show the pyrazine-2-carboxylato moiety to act as an N,O-chelating ligand, while the structure analyses of 5–7, confirm that the pyrazine-2,5-dicarboxylato unit bridges two metal centres. The electrochemical behaviour of selected representatives has been studied by voltammetric techniques.