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Therrien, Bruno

Nom
Therrien, Bruno
Affiliation principale
Fonction
Professeur titulaire
Email
bruno.therrien@unine.ch
Identifiants
https://libra.unine.ch/handle/123456789/382
_
0000-0002-0388-2745

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  • Publication
    Accès libre
    Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole N,N-chelating ligand
    (Elsevier, 2010)
    Gras, Michaël
    ;
    Süss-Fink, Georg 
    ;
    Therrien, Bruno 
    ;
    Angela Casini
    ;
    Edafe, Fabio
    ;
    Paul Dyson
    The dinuclear dichloro complexes [(η6-arene)2Ru2(μ-Cl)2Cl2] and [(η5-C5Me5)2M2 (μ-Cl)2Cl2] react with 2-(pyridine-2-yl)thiazole (pyTz) to afford the cationic complexes [(η6-arene)Ru(pyTz)Cl]+ (arene = C6H61, p-iPrC6H4Me 2 or C6Me63) and [(η5-C5Me5)M(pyTz)Cl]+ (M = Rh 4 or Ir 5), isolated as the chloride salts. The reaction of 2 and 3 with SnCl2 leads to the dinuclear heterometallic trichlorostannyl derivatives [(η6-p-iPrC6H4Me)Ru(pyTz)(SnCl3)]+ (6) and [(η6-C6Me6)Ru(pyTz)(SnCl3)]+ (7), respectively, also isolated as the chloride salts. The molecular structures of 4, 5 and 7 have been established by single-crystal X-ray structure analyses of the corresponding hexafluorophosphate salts. The in vitro anticancer activities of the metal complexes on human ovarian cancer cell lines A2780 and A2780cisR (cisplatin-resistant), as well as their interactions with plasmid DNA and the model protein ubiquitin, have been investigated.
  • Publication
    Accès libre
    Cationic half-sandwich complexes (Rh, Ir, Ru) containing 2-substituted-1,8-naphthyridine chelating ligands: Syntheses, X-ray structure analyses and spectroscopic studies
    (2008)
    Prasad, Kota Thirumala
    ;
    Therrien, Bruno 
    ;
    Mohan Rao Kollipara
    Reactions of the dinuclear complexes [(η6-arene)Ru(μ-Cl)Cl]2 (arene = C6H6, p-iPrC6H4Me) and [(η5-C5Me5)M(μ-Cl)Cl]2 (M = Rh, Ir) with 2-substituted-1,8-naphthyridine ligands, 2-(2-pyridyl)-1,8-naphthyridine (pyNp), 2-(2-thiazolyl)-1,8-naphthyridine (tzNp) and 2-(2-furyl)-1,8-naphthyridine (fuNp), lead to the formation of the mononuclear cationic complexes [(η6-C6H6)Ru(L)Cl]+ {L = pyNp (1); tzNp (2); fuNp (3)}, [(η6-p-iPrC6H4Me)Ru(L)Cl]+ {L = pyNp (4); tzNp (5); fuNp (6)}, [(η5-C5Me5)Rh(L)Cl]+ {L = pyNp (7); tzNp (8); fuNp (9)} and [(η5-C5Me5)Ir(L)Cl]+ {L = pyNp (10); tzNp (11); fuNp (12)}. All these complexes are isolated as chloro or hexafluorophosphate salts and characterized by IR, NMR, mass spectrometry and UV/Vis spectroscopy. The molecular structures of [1]Cl, [2]PF6, [4]PF6, [5]PF6 and [10]PF6 have been established by single crystal X-ray structure analysis.