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Therrien, Bruno

Nom
Therrien, Bruno
Affiliation principale
Fonction
Professeur titulaire
Email
bruno.therrien@unine.ch
Identifiants
https://libra.unine.ch/handle/123456789/382
_
0000-0002-0388-2745

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  • Publication
    Métadonnées seulement
    Synthesis, characterisation and in vitro anticancer activity of hexanuclear thiolato-bridged arene ruthenium metalla-prisms
    (2013)
    Furrer, Mona A.
    ;
    Garci, Amine 
    ;
    Denoyelle-Di-Muro, Emmanuel
    ;
    Trouillas, Patrick
    ;
    Giannini, Federico
    ;
    Furrer, Julien
    ;
    Clavel, Catherine M.
    ;
    Dyson, Paul J.
    ;
    Süss-Fink, Georg 
    ;
    Therrien, Bruno 
    Hexanuclear hexacationic thiolato-bridged arene ruthenium metalla-prisms of the general formula [[(?6-p-cymene)Ru]6(?-SR)6(?3-tpt)2][OTf]6 (R = CH2Ph, CH2C6H4-p-tBu, CH2CH2Ph; tpt = 2,4,6-tri-4-pyridyl-1,3,5-triazine), obtained from the self-assembly of dinuclear precursors [(p-cymene)2Ru2(?-SR)2Cl2] with tpt and AgCF3SO3, have been isolated and fully characterized as triflate salts. The metalla-prisms are highly cytotoxic against human ovarian cancer cells, esp. towards the cisplatin-resistant cell line A2780cisR (IC50
  • Publication
    Métadonnées seulement
    Physical and physicochemical stimuli-responsive arene ruthenium metallaprism
    (2012)
    Furrer, Mona A.
    ;
    Furrer, Julien
    ;
    Therrien, Bruno 
    A stimuli-responsive metallaprism I·6CF3SO3- [1, L = ?6-p-cymene, R = C11H23, X = 3-undecyl-2,5-dioxy-2,5-cyclohexadiene-1,4-dionato(2-)] composed of six p-cymene ruthenium corners bridged by 3-undecyl-1,4-benzoquinonato-2,5-diolato ligands and connected by triangular 2,4,6-tri-4-pyridyl-1,3,5-triazine panels has been prepd. by self-assembly of binuclear ruthenium complex [(?6-p-cymene)RuCl(?-O2C6HRO2)RuCl(?6-p-cymene)] with 2,4,6-tri-4-pyridyl-1,3,5-triazine ligands with 87% yield. In soln., the nature of the solvent and the temp. dictate the conformation of the metallaprism. The alkyl chains can either point away from the metallaprism or hide in the hydrophobic environments of the metallaprism. [on SciFinder(R)]
  • Publication
    Métadonnées seulement
    A Cyclometallated Platinum Complex as a Selective Optical Switch for Quadruplex DNA
    (2012)
    Suntharalingam, Kogularamanan
    ;
    Leczkowska, Anna
    ;
    Furrer, Mona A.
    ;
    Wu, Yilei
    ;
    Kuimova, Marina K.
    ;
    Therrien, Bruno 
    ;
    White, Andrew J. P.
    ;
    Vilar, Ramon
    Herein the authors have presented a new cyclometallated platinum(II) complex the emission of which is switch-ed-on in the presence of DNA. The complex interacts with a 1000-fold selectivity with quadruplex DNA over duplex DNA. More interestingly, its emission is switched-on (ca. 35-fold) in the presence of c-Myc gene and 6183 NT quadruplex DNA, but no significant change in intensity was obsd. upon addn. of the same amts. of duplex ds26 DNA (and only a slight change upon addn. of ct-DNA). Upon encapsulation of this complex inside a hexaruthenium cage, the authors have been able to deliver the complex inside living cells, allowing to carry out confocal fluorescence microscopy studies. These studies have shown that the compd. is released from the cage once inside the cell and a considerable amt. of it penetrates the nucleus and localizes in the nucleoli. [on SciFinder(R)]
  • Publication
    Métadonnées seulement
    Delivery of Floxuridine derivatives to cancer cells by water-soluble organometallic cages
    (2012)
    Yi, Jeong Wu
    ;
    Barry, Nicolas P. E.
    ;
    Furrer, Mona A.
    ;
    Zava, Olivier
    ;
    Dyson, Paul J.
    ;
    Therrien, Bruno 
    ;
    Kim, Byeang Hyean
    Ruthenium water-sol. organometallic cage compds., assembled by 1,2,4,5-benzenetetrolato (dobq), 1,4,5,8-naphthalenetetrolato (donq) and 2,4,6-tri-4-pyridyl-1,3,5-triazine (tpt) ligands gave carceplex inclusion compds. I and II (L = ?6-cymene), resp., with amino acids and nucleoside antitumor agent, Floxuridine (2'-deoxy-5-fluorouridine) pyrene conjugates [R = (CH2)3CONHCHYCO2-5'-O-Floxuridine; Y = H, CH2Ph; R = (CH2)3CO2-5'-O-Floxuridine]. The self-assembly of tpt triangular panels with areneruthenium building blocks [(?6-p-cymene)RuCl]2Q (Q = dobq, donq) in the presence of a pyrenyl-nucleoside derivs. (1-R-pyrene), affords the triangular prismatic host-guest compds. I and II [(pyrene-R)?1]6+ and [(pyrene-R)?2]6+, resp. The inclusion of six monosubstituted pyrenyl-nucleosides [1-R-pyrene; R = R1-R6, where R1 = (CH2)3CO2-5'-O-2'-deoxyuridine, R2 = (CH2)3CO2-5-fluoro-5'-O-2'-deoxyuridine, R3 = (CH2)3CONHCH2CO2-5'-O-2'-deoxyuridine, R4 = (CH2)3CONHCH2CO2-5-fluoro-5'-O-2'-deoxyuridine, R5 = (CH2)3CONHCH(CH2Ph)2CO2-5'-O-2'-deoxyuridine, R6 = (CH2)3CONHCH(CH2Ph)CO2-5-fluoro-5'-O-2'-deoxyuridine] has been accomplished. The carceplex nature of [(pyrene-R)?1]6+ with the pyrenyl moiety firmly encapsulated in the hydrophobic cavity of the cage with the nucleoside groups pointing outward was confirmed by NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS), while the host-guest nature of [(pyrene-R)?2]6+ was studied in soln. by NMR techniques. In contrast to the floxuridine compds. used in the clinic, the host-guest complexes are highly water-sol. Consequently, the cytotoxicities of these water-sol. compds. have been established using human ovarian A2780 and A2780cisR cancer cells. All the host-guest systems are more cytotoxic than the empty cages alone ([1][CF3SO3]6, IC50 = 23 ?M; [2][CF3SO3]6, IC50 = 10 ?M), the most active compd. [1-R4-pyrene?1][CF3SO3]6 being 2 orders of magnitude more cytotoxic (IC50 = 0.3 ?M) on these human ovarian cancer cell lines (A2780 and A2780cisR). [on SciFinder(R)]