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Therrien, Bruno

Nom
Therrien, Bruno
Affiliation principale
Fonction
Professeur titulaire
Email
bruno.therrien@unine.ch
Identifiants
https://libra.unine.ch/handle/123456789/382
_
0000-0002-0388-2745

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  • Publication
    Métadonnées seulement
    The influence of RAPTA moieties on the antiproliferative activity of peripheral-functionalised poly(salicylaldiminato) metallodendrimers
    (2013)
    Govender, Preshendren
    ;
    Sudding, Lara C.
    ;
    Clavel, Catherine M.
    ;
    Dyson, Paul J.
    ;
    Therrien, Bruno 
    ;
    Smith, Gregory S.
    Cationic N,O-chelating dendrimers functionalised on the periphery with RAPTA-like (ruthenium(II)-arene-1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane) moieties have been synthesized and characterized using NMR and IR spectroscopy, elemental anal. and MALDI-TOF/HR-ESI mass spectrometry. Metallodendrimers from the first to the fourth-generation contg. up to 32 peripheral ruthenium-arene-PTA moieties were obtained. Model mononuclear analogs, [{Ru(?6-p-cymene)((C7H5NO)-?2-N,O)(PTA)}((CH2)3)][PF6] and [{Ru(?6hexamethylbenzene)((C7H5NO)-?2-N,O)(PTA)}((CH2)3)][PF6], have been prepd. and their structures were detd. by single crystal X-ray diffraction anal. The cytotoxicities of the metallodendrimers and their mononuclear analogs were established on A2780 and A2780cisR human ovarian carcinoma cancer cells and model human embryonic kidney (HEK) cells. [on SciFinder(R)]
  • Publication
    Métadonnées seulement
    Synthesis, characterisation and in vitro anticancer activity of hexanuclear thiolato-bridged arene ruthenium metalla-prisms
    (2013)
    Furrer, Mona A.
    ;
    Garci, Amine 
    ;
    Denoyelle-Di-Muro, Emmanuel
    ;
    Trouillas, Patrick
    ;
    Giannini, Federico
    ;
    Furrer, Julien
    ;
    Clavel, Catherine M.
    ;
    Dyson, Paul J.
    ;
    Süss-Fink, Georg 
    ;
    Therrien, Bruno 
    Hexanuclear hexacationic thiolato-bridged arene ruthenium metalla-prisms of the general formula [[(?6-p-cymene)Ru]6(?-SR)6(?3-tpt)2][OTf]6 (R = CH2Ph, CH2C6H4-p-tBu, CH2CH2Ph; tpt = 2,4,6-tri-4-pyridyl-1,3,5-triazine), obtained from the self-assembly of dinuclear precursors [(p-cymene)2Ru2(?-SR)2Cl2] with tpt and AgCF3SO3, have been isolated and fully characterized as triflate salts. The metalla-prisms are highly cytotoxic against human ovarian cancer cells, esp. towards the cisplatin-resistant cell line A2780cisR (IC50
  • Publication
    Métadonnées seulement
    Neutral and cationic multinuclear half-sandwich rhodium and iridium complexes coordinated to poly(propyleneimine) dendritic scaffolds: Synthesis and cytotoxicity
    (2013)
    Payne, Richard
    ;
    Govender, Preshendren
    ;
    Therrien, Bruno 
    ;
    Clavel, Catherine M.
    ;
    Dyson, Paul J.
    ;
    Smith, Gregory S.
    The development of multinuclear pentamethylcyclopentadienyl (Cp*) rhodium and iridium complexes from first- and second-generation 2-iminopyridyl and salicylaldimine based poly(propyleneimine) dendrimer scaffolds of the type, DAB-(NH2)n (n = 4 or 8, DAB = diaminobutane) has been accomplished. Eight compds. were synthesized, viz. (Cp*MCl)4Gn (1-8), by first reacting DAB-(NH2)n with either 2-pyridinecarboxaldehyde or salicylaldehyde and subsequently metalating the Schiff-base dendrimers with [Cp*MCl2]2 (where M = Rh, Ir). Related mononuclear complexes [Cp*MCl(L)] (L = iminopyridyl or salicylaldimine) (9-12) were obtained in a similar manner. The mol. structures of 9-12 have been detd. by single-crystal x-ray diffraction anal. and the in vitro anticancer activities of 1-12 were evaluated against the A2780 and A2780cisR human ovarian carcinoma cell lines. [on SciFinder(R)]
  • Publication
    Métadonnées seulement
    Antiproliferative activity of chelating N,O- and N,N-ruthenium(II) arene functionalized poly(propyleneimine) dendrimer scaffolds
    (2011)
    Govender, Preshendren
    ;
    Renfrew, Anna K.
    ;
    Clavel, Catherine M.
    ;
    Dyson, Paul J.
    ;
    Therrien, Bruno 
    ;
    Smith, Gregory S.
    Chelating neutral (N,O) and cationic (N,N) first- and second-generation ruthenium(ii) arene metallodendrimers based on poly(propyleneimine) dendrimer scaffolds were obtained from dinuclear arene ruthenium precursors by reactions with salicylaldimine and iminopyridyl dendritic ligands, resp. The N,N cationic complexes were isolated as hexafluorophosphate salts and were characterized by NMR and IR spectroscopy, and MALDI-TOF mass spectrometry. Related mononuclear complexes were obtained in a similar manner and their mol. structures have been detd. by x-ray diffraction anal. The cytotoxicities of the mono- and multinuclear complexes were established using A2780 and A2780cisR human ovarian carcinoma cancer cell lines. [on SciFinder(R)]