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Therrien, Bruno
Nom
Therrien, Bruno
Affiliation principale
Fonction
Professeur titulaire
Email
bruno.therrien@unine.ch
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3 Résultats
Voici les éléments 1 - 3 sur 3
- PublicationAccès libreRemarkable Anticancer Activity of Triruthenium-Arene Clusters Compared to Tetraruthenium-Arene Clusters(2007)
; ; Dyson, Paul J.The in vitro activity of a series of ruthenium clusters, [(η6-C6H6)(η6-C6Me6)2Ru3 (μ-H)3 (μ3-O)][BF4], [(η6-C6H6)(η6-1,4-iPrC6H4Me)(η6-C6Me6)Ru3 (μ-H)3 (μ3-O)][BF4], [(η6-C6H6)4Ru4 (μ-H)4][BF4]2, [(η6-C6H5Me)4Ru4 (μ-H)4][BF4]2 and [(η6-C6H6)4Ru4 (μ-H)3 (μ-OH)][Cl]2, has been evaluated against A2780 and A2780cisR ovarian carcinoma cell lines. Both triruthenium clusters are very active compared to ruthenium compounds in general, whereas the tetraruthenium clusters do not display significant cytotoxicities. Since the triruthenium clusters are known to form supramolecular interactions with arenes and other functions, it is possible that such interactions are also important with respect to their mode of biological activity. The X-ray structure analysis of [(η6-C6H5Me)4Ru4 (μ-H)4][PF6]2 is also reported. - PublicationAccès libreAn iterative strategy for the synthesis of oligothiophenes by catalytic cross-coupling reactions(2004)
; ; An iterative strategy for the synthesis of new sulfur-functionalized oligothiophenes by Suzuki or Stille cross-coupling reactions was applied to the reaction of 4-bromo-tert-butylphenylthioether with thiophene derivatives. The planarity of the oligothiophenes obtained was confirmed by the single-crystal X-ray structure analysis of 2-(4-tert-butylthiophenyl)thiophene, which shows a potentially large electronic conjugation length. - PublicationAccès libreDendritic Systems Based on Dinuclear Ruthenium or Rhodium Units Generating Peripheral Catalytic Sites(2002)
; Nous avons synthétisé et caractérisé les nouveaux cations dendritiques 1-4 contenant les unités Ru2S3 ou Rh2S3. L'analyse de la structure aux rayons X de 2-Cl montre un coeur Rh2S3à géométrie bipyramide trigonale. La réaction des groupements OH périphériques avec l'acide 2-diphénylphosphinobenzoïque permet la formation des cations dendritiques 5-8 fonctionnalisés par des phosphines. Le cation 5 qui contient deux atomes de ruthénium au centre et trois fonctions PPh2 à la périphérie peut servir de ligand avec le rhodium(I) et permettre d'augmenter significativement l'activité catalytique du précurseur [{Rh(CO)2Cl}2] pour la carbonylation du méthanol., A series of dendritic cations 1-4 containing Ru2S3 or Rh2S3 units, either in the core or in the dendrons, has been synthesized and characterized. The X-ray crystal structure analysis of 2-Cl shows a trigonal bipyramidal Rh2S3 core with propeller-like para-hydroxyphenyl substituents at the sulfur atoms. Reaction of the peripheral OH groups with diphenylphosphino benzoic acid results in the formation of phosphine-functionalized dendritic cations 5-8. The ruthenium-containing cation 5, with three PPh2 functions at the periphery, acts as ligand for rhodium(I) and enhances significantly the catalytic activity of [{Rh(CO)2Cl}2] for the carbonylation of methanol.