Deschenaux, Robert

2011, Pitto-Barry, Anaïs, Barry, Nicolas P. E., Zava, Olivier, Deschenaux, Robert, Therrien, Bruno

Two generations of lipophilic pyrenyl functionalized poly(benzyl ether) dendrimers (P₁ and P₂) have been synthesized. The thermal properties of the two functionalized dendrimers have been investigated, and the pyrenyl group of the dendritic molecules encapsulated in the arene–ruthenium metalla-cage, [Ru₆(p-cymene)₆(tpt)₂(donq)₃]⁶⁺ ([1]⁶⁺) (tpt=2,4,6-tri(pyridin-4-yl)-1,3,5-triazine; donq=5,8-dioxydo-1,4-naphthoquinonato). The host–guest properties of [P1⊂1]⁶⁺ and [P2⊂1]⁶⁺ were studied in solution by NMR and UV/Vis spectroscopic methods, thus allowing the determination of the affinity constants. Moreover, the cytotoxicity of these water-soluble host–guest systems was evaluated on human ovarian cancer cells.

2011, Pitto-Barry, Anais, Barry, Nicolas P. E., Zava, Olivier, Deschenaux, Robert, Dyson, Paul J., Therrien, Bruno

The self-assembly of 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine (tpt) triangular panels with p-cymene-ruthenium building blocks and 5,8-dioxido-1,4-naphthoquinonato (donq) bridges, in the presence of pyrenyl-contg. dendrimers of different generations (P0, P1 and P2), affords the triangular prismatic host-guest compds. [Pn?Ru6(p-cymene)6(tpt)2(donq)3]6+ ([Pn?1]6+). The host-guest nature of these systems, with the pyrenyl moiety being encapsulated in the hydrophobic cavity of the cage and the dendritic functional group pointing outwards, was confirmed by NMR spectroscopy (1H, 2D and DOSY). The host-guest properties of these systems were studied in soln. by NMR and UV/Vis spectroscopic methods, allowing the detn. of their affinity consts. (Ka). Moreover, the ability of these water-sol. host-guest systems to carry the pyrenyl-contg. dendrimers into cancer cells was evaluated on human ovarian cancer cells. The host-guest systems are all more cytotoxic than the empty cage [1][CF3SO3]6 (IC50?4 ?M), with the most active compd., [P0?1][CF3SO3]6, being an order of magnitude more cytotoxic. [on SciFinder(R)]

2011, Pitto-Barry, Anaïs, Barry, Nicolas P. E., Zava, Olivier, Deschenaux, Robert, Dyson, Paul J., Therrien, Bruno

The self-assembly of 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine (tpt) triangular panels with p-cymene–ruthenium building blocks and 5,8-dioxido-1,4-naphthoquinonato (donq) bridges, in the presence of pyrenyl-containing dendrimers of different generations (P₀, P₁ and P₂), affords the triangular prismatic host–guest compounds [Pn⊂Ru₆(p-cymene)₆(tpt)₂(donq)₃]⁶⁺ ([Pn⊂1]⁶⁺). The host–guest nature of these systems, with the pyrenyl moiety being encapsulated in the hydrophobic cavity of the cage and the dendritic functional group pointing outwards, was confirmed by NMR spectroscopy (¹H, 2D and DOSY). The host–guest properties of these systems were studied in solution by NMR and UV/Vis spectroscopic methods, allowing the determination of their affinity constants (K_a). Moreover, the ability of these water-soluble host–guest systems to carry the pyrenyl-containing dendrimers into cancer cells was evaluated on human ovarian cancer cells. The host–guest systems are all more cytotoxic than the empty cage [1][CF₃SO₃]₆ (IC₅₀≈4 μM), with the most active compound, [P0⊂1][CF₃SO₃]₆, being an order of magnitude more cytotoxic.