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Gern, Lise

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Gern, Lise
Affiliation principale
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Ancien.ne collaborateur.trice
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https://libra.unine.ch/handle/123456789/303

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  • Publication
    Métadonnées seulement
    Infection of Ixodes ricinus (Acari : Ixodidae) by Borrelia burgdorferi sensu lato in North Africa
    (1999)
    Zhioua, Elyes
    ;
    Bouattour, Ali
    ;
    Hu, Chang Min
    ;
    Gharbi, Mohamed
    ;
    Aeschliman, Andre
    ;
    Ginsberg, Howard S
    ;
    Gern, Lise 
    Free-living adult Ixodes ricinus. were collected in Amdoun, situated in the Kroumiry mountains in northwestern Tunisia (North Africa). Using direct fluorescence antibody assay, the infection rate of field-collected I. ricinus bq Borrelia burgdorferi sensu late was 30.5% (n = 72). No difference in infection rate was observed between male and female ticks. Spirochetes that had been isolated from I. ricinus from Ain Drahim (Kroumiry Mountains) in 1988 were identified as Borrelia lusitaniae (formerly genospecies PotiB2). This is the first identification of a genospecies of Borrelia burgdorferi sensu lato from the continent of Africa.
  • Publication
    Métadonnées seulement
    Immunization with a polyvalent OspA vaccine protects mice against Ixodes ricinus tick bites infected by Borrelia burgdorferi ss, Borrelia garinii and Borrelia afzelii
    (1997)
    Gern, Lise 
    ;
    Hu, Chang Min
    ;
    Voet, Pierre
    ;
    Hauser, Pierre
    ;
    Lobet, Yves
    Sequence variability of the outer surface protein (Osp) A among Borrelia burgdorferi sl species suggests that a monovalent OspA vaccine may not protect against the various Borrelia present in Eurasia. Here, we confirmed that a monovalent recombinant OspA (rOspA) vaccine noes not protect mice against Ixodes ricinus mediated infection with B. burgdorferi ss, Borrelia garinii and Borrelia afzelii. However when mice were vaccinated with a cocktail of various rOspA from these three species, they were protected, and all challenge ricks that fed on them were cleared of their spirochetes. These results showed that a multiple OspA antigens vaccine, compatible with human use, was very efficient at protecting mice against B. burgdorferi ss, B. garinii and B. afzelii. (C) 1997 Elsevier Science Ltd.