Institut de chimie

2003, Lichtsteiner, Salome, Rizzotti, Sven, Weber, Christina, Vogtli, Alexander, Burkhart, Helmar, Neier, Reinhard, Khov-Tran, Van Van, Folkers, Gerd, Ernst, Beat

The project Pharmasquare (Pharma2) is based on the regular course "Pharmaceutical Chem.: Drug Effects on the Mol. Level" alternately presented in Zurich and Basel using the videoconferencing system Telepoly. The course is part of an open learning environment, which is currently complemented by distant learning facilities including a virtual learning environment. Pharma2 receives financial support from the Swiss Virtual Campus, the ETHZ, and matching funds by the Universities of Basel and Neuchatel. In its final form, the virtual learning environment will offer web-based training modules, a virtual lab., the adaptive self-assessment system PharmAskYou, scripts of the Telepoly lectures including learning objectives, a glossary in pharmaceutical sciences, a news-platform, a discussion forum and the "Question of the Week". [on SciFinder(R)]

2015-4-7, Therrien, Bruno

2013, Govender, Preshendren, Sudding, Lara C., Clavel, Catherine M., Dyson, Paul J., Therrien, Bruno, Smith, Gregory S.

Cationic N,O-chelating dendrimers functionalised on the periphery with RAPTA-like (ruthenium(II)-arene-1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane) moieties have been synthesized and characterized using NMR and IR spectroscopy, elemental anal. and MALDI-TOF/HR-ESI mass spectrometry. Metallodendrimers from the first to the fourth-generation contg. up to 32 peripheral ruthenium-arene-PTA moieties were obtained. Model mononuclear analogs, [{Ru(?6-p-cymene)((C7H5NO)-?2-N,O)(PTA)}((CH2)3)][PF6] and [{Ru(?6hexamethylbenzene)((C7H5NO)-?2-N,O)(PTA)}((CH2)3)][PF6], have been prepd. and their structures were detd. by single crystal X-ray diffraction anal. The cytotoxicities of the metallodendrimers and their mononuclear analogs were established on A2780 and A2780cisR human ovarian carcinoma cancer cells and model human embryonic kidney (HEK) cells. [on SciFinder(R)]

2005, Campidelli, Stephane, Lenoble, Julie, Barbera, Joaquin, Paolucci, Francesco, Marcaccio, Massimo, Paolucci, Demis, Deschenaux, Robert

[60]Fullerene-contg. liq.-cryst. dendrimers were synthesized from the first to the fourth generation by applying the 1,3-dipolar cycloaddn. reaction from a mesomorphic dendritic-type aldehyde deriv., sarcosine (N-methylglycine) or glycine and C60. The cyanobiphenyl unit was used as a liq.-cryst. promoter. With the exception of the first-generation fullerene dendrimer, which was found to be nonmesomorphic, all fullerene-based dendrimers gave rise to a smectic A phase. The liq.-cryst. fullerenes led to two different supramol. organizations within the smectic layers: for the second-generation dendrimers, the mols. are oriented in a head-to-tail fashion within the layers; for each mol. the cyanobiphenyl units point in the same direction. For the dendrimers of third and fourth generations, the dendritic core extends laterally, parallel to the layer planes; the mesogenic units are oriented above and below the dendritic core. For the aldehyde precursors, only one organization inside the layers was obtained, similar to the one obsd. for the third and fourth fullerene-based dendrimers. Cyclic voltammetry investigations displayed several one-electron and multielectron redn. processes; no significant interaction in the ground state between the fullerene and the dendrimer was noticed. The title compds. showed the typical electrochem. stability of fulleropyrrolidines. [on SciFinder(R)]

1993, Meister, Gotz, Stoeckli-Evans, Helen, Süss-Fink, Georg

1994, Meister, Gotz, Rheinwald, Gerd, Stoeckli-Evans, Helen, Süss-Fink, Georg

1995, Shul'pin, Georgiy B, Süss-Fink, Georg

2000, Therrien, Bruno, Ward, Thomas R.

To address the question of the role of chirality at the metal in enantioselective catalysis, a pseudo-tetrahedral three-legged piano-stool complex was prepd., i.e. [RuCl(C26H27N2P)](CF3SO3). Crystallog. data are given. Anchoring a phosphine and a pyrazole tether to an arene (PArN) yields, after ?6:?1:?1 coordination to Ru, [{?6:?1:?1-(PArN)}RuCl]+ as a 1:1 mixt. of enantiomers. Unfortunately, all attempts to resolve the enantiomers failed. The structure soln. revealed racemic crystals. [on SciFinder(R)]

1980, Süss-Fink, Georg

2003, Cabort, Amel, Therrien, Bruno, Bernauer, Klaus, Süss-Fink, Georg

Copper(II) azido complexes contg. a tridentate trinitrogen ligand, [Cu(?3-L)(N3)]+ [L = 2,6-bis(3,4-dihydro-2H-pyrrol-5-yl)pyridine] as well as [Cu(?3-R,S-LH4)(N3)]+, [Cu(?3-S,S-LH4)(N3)]+ and [Cu(?3-R,R-LH4)(N3)]+ [LH4 = 2,6-bis(pyrrolidin-2-yl)pyridine] were synthesized from Cu(ClO4)2·6H2O, NaN3 and the corresponding tridentate ligand and crystd. from methanol as the perchlorate salts. The single crystal x-ray structure analyses show these complexes to form 1-dimensional networks by Cu···N(azide) intermol. interactions, depending on the conformation of the tridentate ligand. In the case of L, an excess of sodium azide gives [Cu(?3-L)(N3)]2[Cu2Cl2(N3)4], the crystal structure anal. of which reveals a surprising tridimensional network of cationic and anionic copper(II) complexes linked by Cu···N(azide) and Cu···N(L) interactions. [on SciFinder(R)]