Neutral and cationic osmium(II)-arene metallodendrimers: Synthesis, characterisation and anticancer activity
Author(s)
Govender, Preshendren
Edafe, Fabio
Makhubela, Banothile C. E.
Dyson, Paul J.
Smith, Gregory S.
Date issued
2014
In
Inorg. Chim. Acta
Vol
PB
No
409
From page
112
To page
120
Subjects
cymeneosmium complex cyclometalation Schiff base salicylaldimine dendritic scaffold cymene osmium salicylaldimine metallodendrimer prepn cytotoxicity anticancer agent crystal structure neutral cationic cymene osmium salicylaldimine metallodendrimer mol structure neutral cationic cymene osmium salixylaldimine metallodendrimer
Abstract
Two neutral and two cationic half-sandwich Os(II)-arene metallodendrimers, [DAB-PPI-{(?6-p-cym)Os((C7H5NO)-?2-N,O)Cl}n] and [DAB-PPI-{(?6-p-cym)Os((C6H5N2)-?2-N,N)Cl}n][PF6]n (n = 4 (G1) or 8 (G2)) were synthesized. Two cationic half-sandwich Os(II)-arene metallodendrimers, contg. PTA (1,3,5-triaza-7-phosphatricyclo[3.3.1.1.] decane), [DAB-PPI-{(?6-p-cym)Os((C7H5NO)-?2-N,O)PTA}n][PF6]n are also reported. All complexes were characterized using anal. (i.e. HR-ESI or EI mass spectrometry and elemental anal.) and spectroscopic (i.e.1H, 13C{1H} NMR and IR) methods. Model mononuclear analogs were prepd. and their mol. structures detd. by single-crystal x-ray crystallog. The cytotoxicity of the complexes were evaluated against the A2780 and A2780cisR human ovarian carcinoma cell lines and some display moderate activity. [on SciFinder(R)]
Publication type
journal article