Thiolato-Bridged Arene-Ruthenium Complexes: Synthesis, Molecular Structure, Reactivity, and Anticancer Activity of the Dinuclear Complexes [(arene)2Ru2(SR)2Cl2]
Author(s)
Ibao, Anne-Flore
Gras, Michael
Zava, Olivier
Dyson, Paul J.
Date issued
2012
In
Eur. J. Inorg. Chem.
Vol
9
No
2012
From page
1531
To page
1535
Subjects
ruthenium cymene dimer thiolato bridged prepn antitumor ovarian cancer crystal structure cymene ruthenium dimer thiolato bridged prepn mol structure cymene ruthenium dimer thiolato bridged
Abstract
Treatment of an arene-Ru dichloride dimer with thiols RSH to lead to cationic trithiolato complexes [(arene)2Ru2(SR)3]+ proceeds through the neutral thiolato complexes [(arene)2Ru2(SR)2Cl2], which were isolated and characterized for arene = p-MeC6H4CHMe2 and R = CH2Ph (1), CH2CH2Ph (2), CH2C6H4CMe3 (3), and C6H11 (4). The single-crystal x-ray structure anal. of the p-tert-butylbenzyl deriv. 3 reveals that the two Ru atoms are bridged by the two thiolato ligands without a metal-metal bond. The neutral dithiolato complexes[(arene)2Ru2(SR)2Cl2] (1-3) are intermediates in the formation of the cationic trithiolato complexes [(arene)2Ru2(SR)3]+ (5-7). Of the new [(arene)2Ru2(SR)2Cl2] complexes, deriv. 2 is highly cytotoxic against human ovarian cancer cells, with IC50 values of 0.20 ? for the A2780 cell line and 0.31 for the cisplatin-resistant cell line A2780cisR. [on SciFinder(R)]
Publication type
journal article