Novel osmium(II)-cymene complexes containing curcumin and bisdemethoxycurcumin ligands
Author(s)
Pettinari, Riccardo
Fabio Marchetti
Di Nicola Corrado
Università di Camerino
Pettinari, Claudio
Università di Camerino
Cuccioloni, Massimiliano
University of Camerino
Bonfili, Laura
Università degli Studi di Camerino, Università di Camerino
Eleuteri Anna Maria
Universita' degli Studi di CAMERINO, University of Camerino
Lucinda K. Batchelor
Dyson, Paul
École polytechnique fédérale de Lausanne Faculté des sciences de base
Date issued
August 6, 2019
In
Inorganic Chemistry Frontiers
No
6
From page
2448
To page
2457
Reviewed by peer
1
Abstract
The first examples of (arene)Os(II) curcuminoid derivatives have been prepared and characterized. The neutral complexes [(p-cym)Os(curc)Cl] (1) and [(p-cym)Os(bdcurc)Cl] (2), together with the cationic derivatives [(p-cym)Os(curc)(PTA)][SO3CF3] (3) and [(p-cym)Os(bdcurc)(PTA)][SO3CF3] (4) (PTA = 1,3,5 triaza-7-phosphaadamantane) were characterized by NMR spectroscopy and ESI mass spectrometry, and the crystal structure of 1 was determined by X-ray diffraction analysis. The cytotoxicity of the complexes was evaluated in vitro against human ovarian carcinoma cells (A2780 and A2780cisR), as well as against non-tumorous Human Embryonic Kidney cells (HEK293). Binding of the complexes to potential pharmacological targets and serum carriers was also explored.
Publication type
journal article
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