Arene-ruthenium complexes with ferrocene-derived ligands: Synthesis and characterization of complexes of the type [Ru(?6-arene)(NC5H4CH2NHOC-C5H4FeC5H5)Cl2] and [Ru(?6-arene)(NC3H3N(CH2)2O2C-C5H4FeC5H5)Cl2]
Author(s)
Auzias, Mathieu
Gueniat, Joel
Renfrew, Anna K.
Dyson, Paul J.
Date issued
2009
In
J. Organomet. Chem.
Vol
6
No
694
From page
855
To page
861
Subjects
arenedichlororuthenium dimer reaction pyridylferrocene imidazolylferrocene ferrocenecarboxylic acid chloride reaction picolylamine hydroxyethylimidazole arenedichlororuthenium dimer crystal structure areneruthenium pyridylferrocene imidazolylferrocene prepn carcinostatic ovarian carcinoma mol structure areneruthenium pyridylferrocene imidazolylferrocene prepn carcinostatic ovarian carcinoma
Abstract
Pyridylferrocene and imidazolylferrocene arene-Ru complexes [Ru(?6-arene)(L)Cl2] where L = NC5H4CH2NHOCC5H4FeC5H5, arene = p-iPrC6H4Me (1) or C6Me6 (2); L = NC3H3N(CH2)2O2CC5H4FeC5H5, arene = p-iPrC6H4Me (3) or C6Me6 (4), and diruthenium-arene complexes [Ru(?6-arene)Cl2]2(L) where L = 1,1'-(NC5H4CH2NHOC)2C5H4FeC5H4, arene = p-iPrC6H4Me (5) or C6Me6 (6); L = 1,1'-(NC3H3N(CH2)2O2C)2C5H4FeC5H4, arene = p-iPrC6H4Me (7) or C6Me6 (8) were synthesized and characterized. The mol. structures of 1 and 3 were confirmed by single-crystal x-ray diffraction. The in vitro anticancer activities of complexes 1-8 were studied comparatively to the uncoordinated ligands. The complexes exhibit fairly low cytotoxicities in comparison to related ferrocene-derived arene-Ru complexes. [on SciFinder(R)]
Publication type
journal article