Neutral and cationic multinuclear half-sandwich rhodium and iridium complexes coordinated to poly(propyleneimine) dendritic scaffolds: Synthesis and cytotoxicity
Author(s)
Payne, Richard
Govender, Preshendren
Clavel, Catherine M.
Dyson, Paul J.
Smith, Gregory S.
Date issued
2013
In
J. Organomet. Chem.
No
729
From page
20
To page
27
Subjects
neutral cationic multinuclear half sandwich rhodium iridium polypropyleneimine complex iminopyridyl pentamethylcyclopentadienyl rhodium iridium complex prepn crystal mol structure antitumor activity iminopyridyl dendrimer pentamethylcyclopentadienyl rhodium iridium complex
Abstract
The development of multinuclear pentamethylcyclopentadienyl (Cp*) rhodium and iridium complexes from first- and second-generation 2-iminopyridyl and salicylaldimine based poly(propyleneimine) dendrimer scaffolds of the type, DAB-(NH2)n (n = 4 or 8, DAB = diaminobutane) has been accomplished. Eight compds. were synthesized, viz. (Cp*MCl)4Gn (1-8), by first reacting DAB-(NH2)n with either 2-pyridinecarboxaldehyde or salicylaldehyde and subsequently metalating the Schiff-base dendrimers with [Cp*MCl2]2 (where M = Rh, Ir). Related mononuclear complexes [Cp*MCl(L)] (L = iminopyridyl or salicylaldimine) (9-12) were obtained in a similar manner. The mol. structures of 9-12 have been detd. by single-crystal x-ray diffraction anal. and the in vitro anticancer activities of 1-12 were evaluated against the A2780 and A2780cisR human ovarian carcinoma cell lines. [on SciFinder(R)]
Publication type
journal article