Novel bioconjugates of aminolevulinic acid with vitamins
Author(s)
Date issued
2008
In
Org. Lett.
Vol
20
No
10
From page
4453
To page
4455
Subjects
Vitamins Role: RCT (Reactant) RACT (Reactant or reagent) (prepn. of biotin aminolevulinic acid conjugate via redn./amidation of biotin pentafluorophenyl ester with (azido)oxopentanoate) vitamin aminolevulinic acid conjugate prepn
Abstract
5-Aminolevulinic acid (ALA) and derivs. thereof have been successfully used in photodynamic cancer therapy (PDT). The synthesis of novel bioconjugates combining ALA with two lipophilic and one hydrophilic vitamins is reported. The new bioconjugates allow studying the potential synergies between the two components in PDT. The synthetic methodol. is robust giving the bioconjugates in good to satisfactory yield. [on SciFinder(R)]
Publication type
journal article