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Synthesis, Molecular Structure, and Anticancer Activity of Cationic Arene Ruthenium Metallarectangles
Auteur(s)
Mattsson, Johan
Govindaswamy, Padavattan
Renfrew, Anna K.
Dyson, Paul J.
Stepnicka, Petr
Date de parution
2009
In
Organometallics
Vol.
15
No
28
De la page
4350
A la page
4357
Mots-clés
Résumé
Cationic arene ruthenium-based tetranuclear complexes comprising rectangular structures have been obtained from the dinuclear arene ruthenium complexes [Ru2(arene)2(OO?OO)2Cl2] (arene = p-cymene, hexamethylbenzene; OO?OO = 2,5-dihydroxy-1,4-benzoquinonato, 2,5-dichloro-1,4-benzoquinonato) by reaction with pyrazine or bipyridine linkers (N?N = pyrazine, 4,4'-bipyridine, 1,2-bis(4-pyridyl)ethylene) in methanol in the presence of AgO3SCF3, forming tetranuclear cations of general formula [Ru4(arene)4(N?N)2(OO?OO)2]4+. All complexes were isolated in good yield as triflate salts and were characterized by NMR and IR spectroscopy and studied by cyclic voltammetry. The cytotoxicities of the water-sol. compds. of the 4,4'-bipyridine and 1,2-bis(4-pyridyl)ethylene series have been established using ovarian A2780 cancer cells. The large rectangles incorporating 1,2-bis(4-pyridyl)ethylene linkers are ca. 5 times more cytotoxic (IC50 ? 6 ?M) than the 4,4'-bipyridine-contg. cations (IC50 ? 30 ?M). Structural characterization by x-ray diffraction of two representative compds., i.e., the triflate salts of [Ru4(hexamethylbenzene)4(4,4'-bipyridine)2(2,5-dihydroxy-1,4-benzoquinonato)2]4+and [Ru4(hexamethylbenzene)4(1,2-bis(4-pyridyl)ethylene)2(2,5-dichloro-1,4-benzoquinonato)2]4+, reveals differently sized cavities, different flexibilities, and different packing arrangements, suggesting a correlation between these structural properties and the obsd. cytotoxicities. [on SciFinder(R)]
Identifiants
Type de publication
journal article
