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Diastereoselective synthesis of (1S,2S,3R,6S) 3-chloro-3-methyl-6-isopropenyl-1,2-cyclohexanediol via Prins reaction induced by zinc and trimethylsilyl chloride
Auteur(s)
Date de parution
1996
In
Tetrahedron
Vol.
13
No
52
De la page
4645
A la page
4658
Résumé
While attempting to synthesize a potential inhibitor of the biosynthetic step of formation of PEG, a novel catalytic system inducing the Prins reaction was discovered. Treatment of epoxy geranial with Zn and trimethylsilyl chloride gave (1S,2S,3R,6S) 3-Chloro-3-methyl-6-isopropenyl-1,2-cyclohexanediol in high diastereoselcctivity.
Identifiants
Type de publication
journal article
