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Sequence-Selective Recognition of Peptides within the Single Binding Pocket of a Self-Assembled Coordination Cage
Auteur(s)
Tashiro, Shohei
Tominaga, Masahide
Kawano, Masaki
Ozeki, Tomoji
Fujita, Makoto
Date de parution
2005
In
J. Am. Chem. Soc.
Vol.
13
No
127
De la page
4546
A la page
4547
Résumé
The single binding pocket of a self-assembled Pd6L4 coordination cage recognizes oligopeptides in a highly sequence-selective fashion. In particular, the Trp-Trp-Ala sequence is strongly bound by the cavity (Ka ?106 M-1). Tripeptides possessing the same residues but in different sequences (i.e., Trp-Ala-Trp and Ala-Trp-Trp) show much poorer affinity. Even singly mutated tripeptides with arom.-arom.-aliph. sequences of the residues (e.g., Trp-Trp-Gly and Trp-Tyr-Ala) are not recognized efficiently. X-ray anal. and NMR reveal that all residues of the Trp-Trp-Ala sequence cooperatively interact with the cage via CH-? and ?-? interactions. [on SciFinder(R)]
Identifiants
Type de publication
journal article
