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Assembly State of Catalytic Modules as Chiral Switches in Asymmetric Strecker Amino Acid Synthesis
Auteur(s)
Kato, Nobuki
Mita, Tsuyoshi
Kanai, Motomu
Kawano, Masaki
Yamaguchi, Kentaro
Danjo, Hiroshi
Sei, Yoshihisa
Sato, Akihiro
Furusho, Sanae
Shibasaki, Masakatsu
Date de parution
2006
In
J. Am. Chem. Soc.
Vol.
21
No
128
De la page
6768
A la page
6769
Résumé
Self-assembled chiral polymetallic complexes often demonstrate novel properties as asym. catalysts. We report the three-dimensional structures of two such asym. catalysts (crystals A and B) for Strecker ?,?-disubstituted amino acid synthesis. These complexes are constructed via assembly of the same chiral modules derived from D-glucose, but their assembly modes differ. The enantioselectivity in the Strecker reaction was dramatically switched, depending on which assembly mode was used. These findings provide insight into the functional importance of higher-order structures of an artificial catalyst. [on SciFinder(R)]
Identifiants
Type de publication
journal article
