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Syntheses of rhazinilam. A comparative review of forty years of synthetic endeavors
Auteur(s)
Kholod, Inga
Vallat, Olivier
Date Issued
2011
Journal
Heterocycles
Vol.
2
No
82
From page
917
To page
948
Subjects
Abstract
A review. R-(-)-Rhazinilam is a relatively simple but unusual monopyrrolic product isolated from nature. It is probable that R-(-)-rhazinilam is an artifact of the isolation procedure. Seven total syntheses of rhazinilam were described in the literature. The comparison of the published syntheses clearly demonstrates the sensitivity of the pyrrole ring contained in the rhazinilam structure. Despite the spectacular progress in org. synthetic methods only a few synthetic strategies were applied to the total synthesis of rhazinilam. Astonishingly the no. of steps needed from com. starting materials has stayed similar over the almost 40 yr period since the first synthesis was reported in 1973. [on SciFinder(R)]
Publication type
journal article
