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Syntheses of rhazinilam. A comparative review of forty years of synthetic endeavors
Auteur(s)
Kholod, Inga
Vallat, Olivier
Date de parution
2011
In
Heterocycles
Vol.
2
No
82
De la page
917
A la page
948
Mots-clés
Résumé
A review. R-(-)-Rhazinilam is a relatively simple but unusual monopyrrolic product isolated from nature. It is probable that R-(-)-rhazinilam is an artifact of the isolation procedure. Seven total syntheses of rhazinilam were described in the literature. The comparison of the published syntheses clearly demonstrates the sensitivity of the pyrrole ring contained in the rhazinilam structure. Despite the spectacular progress in org. synthetic methods only a few synthetic strategies were applied to the total synthesis of rhazinilam. Astonishingly the no. of steps needed from com. starting materials has stayed similar over the almost 40 yr period since the first synthesis was reported in 1973. [on SciFinder(R)]
Identifiants
Type de publication
journal article
