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Stereoselectivity in reactions of metal complexes. VII. Asymmetric synthesis of amino acids by metal ion-promoted transamination
Auteur(s)
Date de parution
1983
In
Helv. Chim. Acta
Vol.
7
No
66
De la page
2049
A la page
58
Mots-clés
Résumé
Enantioselective synthesis of phenylalanine was performed by reacting phenylpyruvic acid with pyridoxamine followed by ketimine-aldimine isomerization of the resulting Schiff base catalyzed by an optically active copper(II)-complex. UV and CD measurements showed that the enantiomeric excess strongly depends on the reaction conditions and on the reaction time and in favorable cases it reacted values of 80%. The selectivity of the reaction is discussed on the basis of possible structures of the intermediate mixed ligand complex. [on SciFinder(R)]
Identifiants
Type de publication
journal article
