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The "complex-in-a-complex" cations [(acac)2M?Ru6-(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: a trojan horse for cancer cells
Auteur(s)
Govindaswamy, Padavattan
Renfrew, Anna K.
Dyson, Paul J.
Date de parution
2008
In
Angew. Chem., Int. Ed.
Vol.
20
No
47
De la page
3773
A la page
3776
Résumé
The cytotoxicities of the large cationic arene-ruthenium prismatic cage [Ru6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+ (tpt = 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine, dhbq = 2,5-dihydroxy-1,4-benzoquinolato; 16+), and its "complex-in-a-complex" derivs. [(acac)2M-1]6+ (M = Pd, Pt; acac = acetylacetonate), are evaluated in comparison with free [M(acac)2]. The differences in cytotoxicity suggest that, like a "Trojan Horse", leaching of the guest from the cage once inside a cell accelerates and increases the cytotoxic effect. [on SciFinder(R)]
Type de publication
Resource Types::text::journal::journal article
