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Therrien, Bruno
Preferred name
Therrien, Bruno
Main Affiliation
Job title
Professeur titulaire
Email
bruno.therrien@unine.ch
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Research Output
Now showing 1 - 10 of 14
- PublicationOpen AccessRemarkable Anticancer Activity of Triruthenium-Arene Clusters Compared to Tetraruthenium-Arene Clusters(2007)
; ; Dyson, Paul J.The in vitro activity of a series of ruthenium clusters, [(η6-C6H6)(η6-C6Me6)2Ru3 (μ-H)3 (μ3-O)][BF4], [(η6-C6H6)(η6-1,4-iPrC6H4Me)(η6-C6Me6)Ru3 (μ-H)3 (μ3-O)][BF4], [(η6-C6H6)4Ru4 (μ-H)4][BF4]2, [(η6-C6H5Me)4Ru4 (μ-H)4][BF4]2 and [(η6-C6H6)4Ru4 (μ-H)3 (μ-OH)][Cl]2, has been evaluated against A2780 and A2780cisR ovarian carcinoma cell lines. Both triruthenium clusters are very active compared to ruthenium compounds in general, whereas the tetraruthenium clusters do not display significant cytotoxicities. Since the triruthenium clusters are known to form supramolecular interactions with arenes and other functions, it is possible that such interactions are also important with respect to their mode of biological activity. The X-ray structure analysis of [(η6-C6H5Me)4Ru4 (μ-H)4][PF6]2 is also reported. - PublicationOpen AccessX-ray crystallographic study of hydrogen-bonded systems formed between di- and tricarboxylic acids and the trinuclear cluster cation [H3Ru3(C6H6)(C6Me6)2 (O)]+(2005)
; - PublicationOpen AccessX-ray crystallographic study of two dinuclear triply-bridged p-cymene osmium complexes(2005)
; - PublicationOpen AccessHydrogen-bonded systems between monocarboxylic acids and the trinuclear cluster cation [H3Ru3(C6H6)(C6Me6)2(O)]+ : cold-spray ionisation mass spectroscopic and X-ray crystallographic studies(2004-09-01)
; ; - PublicationOpen AccessRuthenium(II) complexes with ferrocene-modified arene ligands: synthesis and electrochemistry(2004)
; - PublicationOpen AccessAn asymmetric trihydrido-bridged arene ruthenium complex(2004)
; Reaction of [Ru(η6-indane)(H2O)3]2+ and [Ru(η6-C6Me6)(H2O)3]2+ with NaBH4 in water gives a mixture of three triple hydrido-bridged arene ruthenium cations [(η6-arene)Ru(μ-H)3Ru(η6-arene′)]+ (arene=indane and hexamethylbenzene; arene′=indane and hexamethylbenzene). After treatment with NaBF4, the three complexes are separated by column chromatography and the asymmetrical [(η6-indane)Ru(μ-H)3Ru(η6-C6Me6)][BF4] (cation 1a) can be isolated in moderate yield. 1a decomposes in solution to give the corresponding hydroxo-bridged complex [(η6-indane)Ru(μ-OH)3Ru(η6-C6Me6)]+ (2) with retention of the asymmetrical geometry as shown by single-crystal X-ray structure analysis. The indane ligand adopts an envelope conformation toward the ruthenium atom. - PublicationOpen Access2,3,4,7-Tetrahydro-1H-inden-2-ol: synthesis, molecular structure and coordination chemistry(2004)
; 2,3,4,7-Tetrahydro-1H-inden-2-ol (1) has been synthesised by Birch reduction of indan-2-ol. A single-crystal X-ray structure analysis of 1 shows the compound to exist as hydrogen-bonded polymers along the c-axis due to the presence of a series of hydrogen-bonds between hydroxo functions. The ferrocene ester derivatives, ferrocene carboxylic acid 2,3,4,7-tetrahydro-1H-inden-2-yl ester (2) and ferrocene carboxylic acid indan-2-yl ester (3) have been prepared by peptidic coupling of ferrocene carboxylic acid with 1 and with indan-2-ol, respectively. The single-crystal X-ray structure analyses of 2 and 3 reveal in both cases the cyclopentadienyl rings to adopt an eclipsed conformation with the indenyl substituent being rotated out of the Cp ester plane by almost 90°, allowing no efficient interaction between the π-system of the Cp ring and the indene moiety. The dienyl derivative 2 reacts with RuCl3 • nH2O in refluxing ethanol to afford [Ru(arene)Cl2]2 (4) (arene=ferrocene carboxylic acid indan-2-yl ester) as a mixture of isomers. - PublicationOpen AccessSupramolecular cluster catalysis : facts and problems(2004)
; ; - PublicationOpen AccessSynthesis and molecular structure of the trinuclear ruthenium cluster cations [H3Ru3{C6H5(CH2)2OC(O)C6H5}(C6Me6)2(O)]+ and [H3Ru3{C6H5(CH2)2OC(O)(CH2)3C6H5}(C6Me6)2(O)]+(2004)
; Benzoic acid 2-cyclohexa-1,4-dienyl ethyl ester (1), and 4-phenylbutyric acid 2-cyclohexa-1,4-dienyl ethyl ester (2) are prepared by reacting, respectively, benzoic acid and 4-phenylbutyric acid with 2-cyclohexa-1,4-dienyl ethanol. These dienyl ester derivatives react with RuCl3• n H2O in refluxing ethanol to afford in good yield [Ru{C6H5(CH2)2OC(O)C6H5}Cl2] 2 (3), and [Ru{C6H5(CH2)2OC(O)(CH2)3C6H5}Cl2]2 (4). The trinuclear arene–ruthenium cluster cations [H3Ru3{C6H5 (CH2)2OC(O)C6H5}(C6Me6)2(O)]+ (5), and [H3Ru3{C6H5(CH2)2OC(O)(CH2)3C6H5}(C6Me6)2(O)]+ (6) are synthesised from the dinuclear precursor [H3Ru2(C6Me6)2]+, and the mononuclear complexes [Ru{C6H5(CH2)2OC(O)C6H5}(H2O)3]2+ and [Ru{C6H5(CH2)2OC(O)(CH2)3C6H5}(H2O)3]2+, accessible, respectively, from 3 and 4 in aqueous solution. The water-soluble trinuclear cluster cations 5, and 6 possess a phenyl substituent attach to their side-arm which can act as a substrate for hydrogenation. The single-crystal X-ray structure analyses of [5][PF6], and [6][PF6] have been determined. - PublicationOpen AccessHost–guest properties of the trinuclear arene–ruthenium cluster cation [H3Ru3(C6H6)(C6Me6)2(O)]+(2004)
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