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Di Francesco, Joab
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Di Francesco, Joab
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Voici les éléments 1 - 5 sur 5
- PublicationMétadonnées seulementInterferometric measurements beyond the coherence length of the laser source(2016-9-19)
; ; ; ; Polster, AlbertInterferometric measurements beyond the coherence length of the laser are investigated theoretically and experimentally in this paper. Thanks to a high-bandwidth detection, high-speed digitizers and a fast digital signal processing, we have demonstrated that the limit of the coherence length can be overcome. Theoretically, the maximal measurable displacement is infinite provided that the sampling rate is sufficiently short to prevent any phase unwrapping error. We could verify experimentally this concept using a miniature interferometer prototype, based on a frequency stabilized vertical cavity surface emitting laser. Displacement measurements at optical path differences up to 36 m could be realized with a relative stability better than 0.1 ppm, although the coherence length estimated from the linewidth and frequency noise measurements do not exceed 6.6 m. - PublicationMétadonnées seulementReal-time Amyloid Aggregation Monitoring with a Photonic Crystal-based Approach(2013)
; ; ; Herzig, Hans PeterWe propose the application of a new label-free optical technique based on photonic nanostructures to real-time monitor the amyloid-beta 1-42 (A?(1-42)) fibrillization, including the early stages of the aggregation process, which are related to the onset of the Alzheimer's Disease (AD). The aggregation of A? peptides into amyloid fibrils has commonly been assocd. with neuronal death, which culminates in the clin. features of the incurable degenerative AD. Recent studies revealed that cell toxicity is detd. by the formation of sol. oligomeric forms of A? peptides in the early stages of aggregation. At this phase, classical amyloid detection techniques lack in sensitivity. Upon a chem. passivation of the sensing surface by means of polyethylene glycol, the proposed approach allows an accurate, real-time monitoring of the refractive index variation of the soln., wherein A?(1-42) peptides are aggregating. This measurement is directly related to the aggregation state of the peptide throughout oligomerization and subsequent fibrillization. Our findings open new perspectives in the understanding of the dynamics of amyloid formation, and validate this approach as a new and powerful method to screen aggregation at early stages. [on SciFinder(R)] - PublicationMétadonnées seulementSi-Interdiffusion in heavily doped AIN-GaN-based quantum well intersubband photodetectors(2011)
; ; - PublicationMétadonnées seulementCO2 isotope sensor using a broadband infrared source, a spectrally narrow 4.4 μm quantum cascade detector and a Fourier spectrometer(2011)
; ; - PublicationMétadonnées seulementPerformance Improvement of AIN-GaN-Based Intersubband Detectors by Using Qantum Dots(2010)
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