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Neier, Reinhard

Nom
Neier, Reinhard
Affiliation principale
Fonction
Professeure ordinaire
Email
Reinhard.Neier@unine.ch
Identifiants
https://libra.unine.ch/handle/123456789/383
_
0000-0003-0890-1797

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  • Publication
    Métadonnées seulement
    Synthesis of Tri- and Tetrasubstituted Furans Catalyzed by Trifluoroacetic Acid
    (2000)
    Stauffer, Frederic
    ;
    Neier, Reinhard 
    Substituted 2-hydroxy-3-acetylfurans are synthesized by alkylation of tert-Bu acetoacetate with an ?-haloketone followed by treatment of the obtained intermediate with trifluoroacetic acid (TFA). A second alkylation of the intermediate followed by treatment with trifluoroacetic acid provides access to disubstituted 2-methylfurans. For example, alkylation of tert-Bu acetoacetate with Me 5-bromolevulinate gave 2-acetyl-4-oxoheptanedioic acid 1-(1,1-dimethylethyl) 7-Me ester. Treatment of the latter with trifluoroacetic acid gave 4-acetyl-5-hydroxy-2-furanpropanoic acid Me ester. [on SciFinder(R)]