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Neier, Reinhard
Nom
Neier, Reinhard
Affiliation principale
Fonction
Professeure ordinaire
Email
Reinhard.Neier@unine.ch
Identifiants
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5 Résultats
Voici les éléments 1 - 5 sur 5
- PublicationAccès libreMacrocyclisation of 2-(5-(2-hydroxyethyl)furan-2-yl)acetic acid model compounds of nonactic acid(2009)
;Eng, Carine ;Simone, Jean-Mary ;Hartenbach, Akane ;Loiseau, FrançoisThe macrocyclisation of hydroxyethylfuranyl acetic acid and of dehydrogenated model compounds of nonactic acid was investigated to develop a facile synthesis of nonactin analogues. By applying the Yamagushi macrocyclisation to our ω-hydroxyacids, we were able to isolate a mixture of di-, tri-, tetra- and pentameric macrocycles. - PublicationAccès libreMalonylation/Decarbalkoxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid Derivatives. Part II [1](2007)
;Simone, Jean-Mary ;Loiseau, François ;Carcache, David ;Bobal, Pavel ;Jeanneret-Gris, JulieA malonylation/decarbalkoxylation sequence from 2-substituted furans was investigated in view of developing a scalable synthesis of hydrophobic nonactic acid analogues. - PublicationAccès libreRadical Couplings as Key Steps for the Preparation of Derivatives of Nonactic Acid(2007)
;Loiseau, François ;Simone, Jean-Mary ;Carcache, David ;Bobal, PavelFree radical couplings from furan, as cheap starting material, were studied in view of developing a rapid strategy en route to the synthesis of derivatives of nonactin. The chain containing the alcohol function was introduced in one or two steps in 86% yield. For the introduction of the second chain with the ester function two different coupling methods were tested. Starting from the advanced intermediates obtained nonactin derivatives can be prepared by catalytic hydrogenation of the furan ring. - PublicationAccès libreMalonylation/Decarbalkoxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid Derivatives. Part I [1](2007)
;Simone, Jean-Mary ;Loiseau, François ;Carcache, David ;Bobal, Pavel ;Jeanneret-Gris, JulieA malonylation/decarbalkoxylation sequence from 2-substituted furans was investigated in view of developing a scalable synthesis of hydrophobic nonactic acid analogues. - PublicationAccès libreAmino-Claisen Rearrangements and Diels-Alder Reactions of Ketene N,O-Acetals: Reactivity Studies. On the Way to a Novel Tandem Process?(2000)
;Neuschütz, Klaus ;Simone, Jean-Mary ;Thyrann, ThomasWe report the synthesis of N-benzyl-N-[(E)-buta-1,3-dienyl]propanamide (6) and its corresponding O-silyl-substituted ketene N,O-acetal 7 and their Diels-Alder reaction. Propanamide 6 reacted smoothly, whereas the yield obtained from 7 was low, probably due to polymerization of the dienophile induced by electron transfer. The ketene N,O-acetals 27a - g were synthesized starting from the corresponding benzamides 25a - e (Scheme 9). The ketene N,O-acetals 27a - g showed increased stabilities and underwent amino-Claisen rearrangements under thermal conditions. Using catalysts, interesting side reactions leading either to the annulated systems rac-35 - 37 or to a β-lactam rac-34 were observed.