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Neier, Reinhard
Nom
Neier, Reinhard
Affiliation principale
Fonction
Professeure ordinaire
Email
Reinhard.Neier@unine.ch
Identifiants
Résultat de la recherche
Voici les éléments 1 - 7 sur 7
- PublicationAccès libreMalonylation/Decarbalkoxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid Derivatives. Part II [1](2007)
- PublicationAccès libreRadical Couplings as Key Steps for the Preparation of Derivatives of Nonactic Acid(2007)
- PublicationAccès libreMalonylation/Decarbalkoxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid Derivatives. Part I [1](2007)
- PublicationMétadonnées seulementA chemical synthesis of porphobilinogen imitating the pathway proposed by Shemin for the biosynthesis: comparing inhibition studies with investigations of chemical reactivity(1999)
; The synthesis of porphobilinogen and related compds. was reviewed with 78 refs. in this conference proceeding. Nature's pathways have been a strong motivation for synthetic chemists. Trying to imitate what has been shown or what is supposed to be a biosynthetic transformation always pursues several objectives: One evident goal is to obtain the natural product via the elegant way used in the natural process. The second not less important goal is to obtain insight into the mechanistic details of the biosynthetic pathway. Finally during the synthetic effort compds. are obtained which are potentially interesting as inhibitors of the natural process. Porphobilinogen, the second dedicated intermediate in the biosynthesis of 'pigments of life' synthesized following the mechanistic rationale proposed 30 yr ago by Shemin for the biosynthesis. Substances obtained during this synthetic effort and inhibitors esp. synthesized for our studies were tested in order to evaluate the different mechanistic proposals. This biomimetic approach allowed to guide at the same time the synthetic as well as the biosynthetic studies. [on SciFinder(R)] - PublicationMétadonnées seulementSynthesis of 3-substituted Analogues of Levulinic Acid via Baylis-Hillman and Mukaiyama Reactions. Potential Inhibitors of Porphobilinogen Synthase.(1998)
; - PublicationMétadonnées seulementA Chemical Synthesis of Porphobilinogen Imitating the Pathway Proposed by Shemin for the Biosynthesis: Comparing Inhibtion Studies with Investigations of Chemical Reality(1998)
; - PublicationAccès libreThe chemical synthesis of porphobilinogen an important intermediate of the biosynthesis of the "pigments of life"(1997)